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      Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation.

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          Abstract

          It has been suggested that the basal forebrain (BF) exerts strong influences on the formation of memory and behavior. However, what information is used for the memory-behavior formation is unclear. We found that a population of neurons in the medial BF (medial septum and diagonal band of Broca) of macaque monkeys encodes a unique combination of information: reward uncertainty, expected reward value, anticipation of punishment, and unexpected reward and punishment. The results were obtained while the monkeys were expecting (often with uncertainty) a rewarding or punishing outcome during a Pavlovian procedure, or unexpectedly received an outcome outside the procedure. In vivo anterograde tracing using manganese-enhanced MRI suggested that the major recipient of these signals is the intermediate hippocampal formation. Based on these findings, we hypothesize that the medial BF identifies various contexts and outcomes that are critical for memory processing in the hippocampal formation.

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          Author and article information

          Journal
          J. Neurosci.
          The Journal of neuroscience : the official journal of the Society for Neuroscience
          Society for Neuroscience
          1529-2401
          0270-6474
          May 13 2015
          : 35
          : 19
          Affiliations
          [1 ] Department of Anatomy and Neurobiology, Washington University, School of Medicine, St. Louis, Missouri 63110, Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland, 20892, and ilya.monosov@gmail.com.
          [2 ] Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health, Bethesda, Maryland 20892, Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, Bethesda, Maryland 20892.
          [3 ] Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland, 20892, and.
          Article
          35/19/7443
          10.1523/JNEUROSCI.0051-15.2015
          4429151
          25972172

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