Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

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Abstract

The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage.

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Author and article information

Journal

Title: Clinical Infectious Diseases

Publisher: Oxford University Press (OUP)

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date Created: June 21 2018

Publication date (Electronic): June 21 2018

Affiliations

[1 ]Department of Pediatric Gastroenterology, Emma Children’s Hospital/Academic Medical Center, Amsterdam

[2 ]Department of Pediatric Gastroenterology, VU University Medical Center, Amsterdam

[3 ]Neonatal Intensive Care Unit, Máxima Medical Center, Veldhoven

[4 ]Neonatal Intensive Care Unit, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children’s Hospital, Nijmegen, The Netherlands

[5 ]Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium

[6 ]Neonatal Intensive Care Unit, Beatrix Children’s Hospital/University Medical Center Groningen

[7 ]Neonatal Intensive Care Unit, VU University Medical Center, Amsterdam

[8 ]Neonatal Intensive Care Unit, Emma Children’s Hospital/Academic Medical Center, Amsterdam

[9 ]Department of Pediatrics, Maastricht University Medical Center, Zwolle

[10 ]Neonatal Intensive Care Unit, Amalia Children’s Centre/Isala, Zwolle

[11 ]Department of Pediatrics, Emma Children’s Hospital/Academic Medical Center, Amsterdam

[12 ]Department of Pediatrics, VU University Medical Center, Amsterdam

[13 ]Neonatal Intensive Care Unit, Wilhelmina Children’s Hospital/University Medical Center Utrecht, The Netherlands

[14 ]School of Engineering, University of Warwick, United Kingdom

[15 ]Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands

Article

DOI: 10.1093/cid/ciy383

PubMed ID: 29931245

SO-VID: 9d0c4868-89a7-4d1e-b9f6-2832ecf0c0dc

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