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      Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.

      Bioorganic & Medicinal Chemistry

      Anti-Bacterial Agents, chemical synthesis, chemistry, pharmacokinetics, Antifungal Agents, Chlorine, Escherichia coli, drug effects, Fluorine, Gram-Positive Cocci, Mannich Bases, Mitosporic Fungi, Molecular Structure, Pseudomonas aeruginosa, Schiff Bases, Structure-Activity Relationship

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          Abstract

          A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.

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          Journal
          16879972
          10.1016/j.bmc.2006.07.015

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