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Abstract
To compare the ocular wavefront aberrations of normal and keratoconic eyes and to
describe the characteristics of the higher-order aberrations in eyes with keratoconus.
Prospective case control and observational study.
Thirty-five keratoconic eyes and thirty-eight normal controls.
Higher-order aberrations in refraction were measured with a wavefront sensor, and
those aberrations resulting from the cornea were evaluated by videokeratographic data.
Coma-like (S(3 + 5)), spherical-like (S(4 + 6)), and total (S(3 + 4 + 5 + 6)) higher-order
aberrations in both refraction and the cornea.
The mean +/- standard deviation of S(3 + 5) (1.88 +/- 1.16), S(4 + 6) (0.70 +/- 0.55),
and S(3 + 4 + 5 + 6) (2.03 +/- 1.23) in refraction (6-mm diameter, root mean square,
micro m) were significantly higher in the keratoconic eyes than in normal controls
(0.26 +/- 0.10, 0.19 +/- 0.10, 0.34 +/- 0.11, respectively; Mann-Whitney U test, P
= 0.001). Coma-like aberrations were 2.32 times larger than spherical-like aberrations
in keratoconic eyes.
The increase of ocular higher-order aberrations in keratoconic eyes results from an
increase of corneal higher-order aberrations. Coma-like aberrations were dominant
compared with spherical-like aberrations in keratoconic eyes. Wavefront sensing will
enable us not only to evaluate the quality of vision but also to differentiate keratoconic
eyes from normal eyes by analyzing the characteristics of the higher-order aberrations.