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      Possible Site of Decreased Intestinal Zinc Absorption in Chronic Uremic Rats

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          Background/Aims: Previous zinc tolerance tests in uremic patients indicated decreased intestinal zinc absorption. In the present study, a zinc tolerance test was initially applied to a uremic rat model and subsequently the possible site of malabsorption investigated. Methods: Chronic uremia was induced by five-sixths nephrectomy. Both control and nephrectomized rats were divided into three groups including animals with intact intestine, removal of the jejunum, and removal of the ileum. Each rat was orally loaded with zinc sulfate (80 mg/kg) in conscious state. Blood samples were drawn before and after zinc load at different intervals during 6 h for zinc analysis. The area under the plasma zinc curve (AUC) and the maximal increase of plasma zinc level (C<sub>max</sub>) were calculated. Results: Jejunectomy decreased both AUC and C<sub>max</sub> in control and nephrectomized rats, whereas ileectomized animals remained, interestingly, unchanged with regard to these two parameters. Significant decreases in both AUC and C<sub>max</sub> were observed in nephrectomized rats as compared with the control rats. Conclusions: The jejunum is the main site of zinc absorption in response to a large oral load of zinc sulfate in both normal and uremic rats. The data further suggest that five-sixths nephrectomy reduces gastrointestinal zinc absorption in rats predominantly by the ileum.

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          Author and article information

          S. Karger AG
          05 September 2001
          : 89
          : 2
          : 208-214
          aDepartment of Physiology, National Yang-Ming University, and bDepartment of Medical Research, Veterans General Hospital, Taipei, Taiwan
          46069 Nephron 2001;89:208–214
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 2, References: 44, Pages: 7
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/46069
          Original Paper

          Cardiovascular Medicine, Nephrology

          Zinc tolerance test, Chronic uremia, Ileum, Zinc, Intestinal absorption


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