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      Possible Site of Decreased Intestinal Zinc Absorption in Chronic Uremic Rats

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          Abstract

          Background/Aims: Previous zinc tolerance tests in uremic patients indicated decreased intestinal zinc absorption. In the present study, a zinc tolerance test was initially applied to a uremic rat model and subsequently the possible site of malabsorption investigated. Methods: Chronic uremia was induced by five-sixths nephrectomy. Both control and nephrectomized rats were divided into three groups including animals with intact intestine, removal of the jejunum, and removal of the ileum. Each rat was orally loaded with zinc sulfate (80 mg/kg) in conscious state. Blood samples were drawn before and after zinc load at different intervals during 6 h for zinc analysis. The area under the plasma zinc curve (AUC) and the maximal increase of plasma zinc level (C<sub>max</sub>) were calculated. Results: Jejunectomy decreased both AUC and C<sub>max</sub> in control and nephrectomized rats, whereas ileectomized animals remained, interestingly, unchanged with regard to these two parameters. Significant decreases in both AUC and C<sub>max</sub> were observed in nephrectomized rats as compared with the control rats. Conclusions: The jejunum is the main site of zinc absorption in response to a large oral load of zinc sulfate in both normal and uremic rats. The data further suggest that five-sixths nephrectomy reduces gastrointestinal zinc absorption in rats predominantly by the ileum.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          2001
          2001
          05 September 2001
          : 89
          : 2
          : 208-214
          Affiliations
          aDepartment of Physiology, National Yang-Ming University, and bDepartment of Medical Research, Veterans General Hospital, Taipei, Taiwan
          Article
          46069 Nephron 2001;89:208–214
          10.1159/000046069
          11549904
          © 2001 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 3, Tables: 2, References: 44, Pages: 7
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/46069
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Zinc tolerance test, Chronic uremia, Ileum, Zinc, Intestinal absorption

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