Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Aim

The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants.

Methods

This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP ( n = 178, control group).

Results

When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development.

Conclusions

Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

Related collections

Author and article information

Journal

Journal ID (nlm-ta): Neonatology

Journal ID (iso-abbrev): Neonatology

Journal ID (publisher-id): NEO

Title: Neonatology

Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.com )

ISSN (Print): 1661-7800

ISSN (Electronic): 1661-7819

Publication date (Print): January 2021

Publication date (Electronic): 8 December 2020

Publication date PMC-release: 8 December 2020

Volume: 117

Issue: 5

Pages: 562-568

Affiliations

[1] ^aNewborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland

[2] ^bDepartment of Child and Adolescent, University Hospital Geneva, Geneva, Switzerland

[3] ^cDepartment of Neonatology, University Hospital Lausanne, Lausanne, Switzerland

[4] ^dDepartment of Neonatology, University Hospital Berne, Berne, Switzerland

[5] ^eDepartment of Neonatology, University of Basel Children's Hospital, Basel, Switzerland

[6] ^fDepartment of Neonatology, Children's Clinic, Cantonal Hospital Aarau, Aarau, Switzerland

[7] ^gDepartment of Neonatology, Children's Hospital of Lucerne, Lucerne, Switzerland

[8] ^hNeonatal and Paediatric Intensive Care Unit, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland

[9] ⁱPaediatric and Neonatal Intensive Care Unit, Department of Paediatrics, Cantonal Hospital Graubuenden, Chur, Switzerland

Author notes

*Tobias Hengartner, Department of Neonatology, University Hospital and University of Zurich, Endlikerstrasse 93, CH −8400 Winterthur (Switzerland), tobias.hengartner@ 123456uzh.ch

Article

Accession ID: PMC7845415 Pmcid ID: PMC7845415 Pmc-uid ID: 7845415 Publisher ID: neo-0117-0562

DOI: 10.1159/000512020

PMC ID: 7845415

PubMed ID: 33291117

SO-VID: 9d6231c0-7e3c-4ea5-9b87-5a9b96d9b9ac

History

Date received : 30 July 2020

Date accepted : 14 September 2020

Date: 2020

Page count

Tables: 6, References: 25, Pages: 7

Comments

Comment on this article

scite_

Cited by 6

See all cited by