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      “Nueva Terapia Antirretroviral Inyectable Aprobada por La FDA para Pacientes Infectados con VIH” Translated title: “New Injectable Antiretroviral Therapy Approved by the FDA for HIV-Infected Patients”


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          Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial

          Cabotegravir and rilpivirine are antiretroviral drugs in development as long-acting injectable formulations. The LATTE-2 study evaluated long-acting cabotegravir plus rilpivirine for maintenance of HIV-1 viral suppression through 96 weeks.
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            Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection

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              Long-acting injectable antiretrovirals for HIV treatment and prevention

              Purpose of review Long-acting antiretroviral (ARV) drugs may improve adherence to therapy and extend opportunities for therapeutic or prophylactic intervention to underserved patient populations. This review focuses on recent advances in the development of small molecule long-acting injectable ARV agents. Recent findings The need for combination ART and physicochemical and dosing limitations of current ARV drugs impede attempts to redevelop them as long-acting injectable formulations. However, the intrinsic properties of rilpivirine, a nonnucleoside reverse transcriptase inhibitor, and GSK1265744, an HIV-1 integrase strand transfer inhibitor, have enabled crystalline nanoparticle formulations to progress to clinical trials. Summary Investigational long-acting injectable nanoformulations of rilpivirine and GSK1265744 are clinical-stage development candidates. Complementary pharmacologic properties of both agents – different mechanisms of action, resistance profiles, metabolic pathways, lack of drug interactions and low daily oral doses – offer the potential for combination use. Phase I studies of the pharmacokinetics and safety of each long-acting formulation alone and in combination indicate that a monthly dosing regimen is possible for HIV treatment. An ongoing phase IIb trial of oral GSK1265744 and oral rilpivirine is evaluating this two-drug regimen for maintenance of virologic suppression; results will inform future studies using the injectable formulations. Additional preclinical and clinical studies indicate a potential use of each agent for HIV pre-exposure prophylaxis.

                Author and article information

                Gaceta Médica Boliviana
                Gac Med Bol
                Facultad de Medicina de la Universidad Mayor de San Simón (Cochabamba, , Bolivia )
                : 44
                : 2
                : 280-281
                [1] La Paz La Paz orgnameUniversidad Mayor de San Andrés orgdiv1Facultad de Medicina,Enfermería, Nutrición y Tecnología Médica Bolivia
                S1012-29662021000200280 S1012-2966(21)04400200280

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                : 26 February 2021
                : 28 April 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 8, Pages: 2

                SciELO Bolivia

                CARTAS AL EDITOR

                rilpivirina.,combinación de fármacos ,cabotegravir


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