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      PHYTOCHEMICAL, PHARMACOLOGICAL AND BIOLOGICAL PROFILES OF TRAGIA SPECIES (FAMILY: EUPHORBIACEAE)

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          Abstract

          Background:

          Tragia belongs to the family Euphorbiaceae which contains about 152 species. Interestingly, most of the earlier investigations have been done using only five Tragia species, namely, Tragia involucrata, Tragia cannabina, Tragia spathulata, Tragia plukenetii, and Tragia benthamii. The objective of the present review is to compile the phytochemical, pharmacological and biological studies of the selected five Tragia species reported in the literature.

          Methods:

          The reported data/information was retrieved mainly from the online databases of PubMed (MEDLINE), EMBASE and Botanical Survey of India.

          Results:

          The present review elaborated the phytochemical, pharmacological and biological properties of the selected five Tragia species obtained from recent literature.

          Conclusion:

          This review provides a basis for future investigation of Tragia species and, especially for those species that have not been explored for biological and pharmacological activities.

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          Most cited references48

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          The evolution of headache from childhood to adulthood: a review of the literature

          Headache is one of the most common disorders in childhood, with an estimated 75% of children reporting significant headache by the age of 15 years. Pediatric migraine is the most frequent recurrent headache disorder, occurring in up to 28% of older teenagers. Headaches rank third among the illness-related causes of school absenteeism and result in substantial psychosocial impairment among pediatric patients. The aim of this study was to clarify the evolution of the clinical features of primary headache in the transition from childhood to adulthood through a review of relevant data available in the PubMed and Google Scholar databases for the period 1988 to July 2013. The search strategy identified 15 published articles which were considered eligible for inclusion in the analysis (i.e. relevant to the investigation of pediatric headache outcome). All were carried out after the publication of the first version of the International Classification of Headache Disorders (ICHD-I). The availability of data on the evolution of primary headaches over a period of time is important from both a clinical and a public health perspective. The identification of prognostic factors of the evolution of headache (remission or evolution into another headache form) over time should be an objective of future headache research for the development of prevention strategies. Given that headache is a major factor contributing to school absenteeism and poorer quality of life not only in childhood but also in adolescence, understanding the natural history and the management of the different headache forms is vital for our future.
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            Unsafe and potentially safe herbal therapies.

            Unsafe and potentially safe herbal therapies are discussed. The use of herbal therapies is on the rise in the United States, but most pharmacists are not adequately prepared educationally to meet patients' requests for information on herbal products. Pharmacists must also cope with an environment in which there is relatively little regulation of herbal therapies by FDA. Many herbs have been identified as unsafe, including borage, calamus, coltsfoot, comfrey, life root, sassafras, chaparral, germander, licorice, and ma huang. Potentially safe herbs include feverfew, garlic, ginkgo, Asian ginseng, saw palmetto, St. John's wort, and valerian. Clinical trials have been used to evaluate feverfew for migraine prevention and rheumatoid arthritis; garlic for hypertension, hyperlipidemia, and infections; ginkgo for circulatory disturbances and dementia; ginseng for fatigue and cancer prevention; and saw palmetto for benign prostatic hyperplasia. Also studied in formal trials have been St. John's wort for depression and valerian for insomnia. The clinical trial results are suggestive of efficacy of some herbal therapies for some conditions. German Commission E, a regulatory body that evaluates the safety and efficacy of herbs on the basis of clinical trials, cases, and other scientific literature, has established indications and dosage recommendations for many herbal therapies. Pharmacists have a responsibility to educate themselves about herbal therapies in order to help patients discern the facts from the fiction, avoid harm, and gain what benefits may be available.
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              Preliminary studies on the anti-inflammatory and analgesic activity of the methanolic fraction of the root extract of Tragia involucrata Linn.

              Tragia involucrata has been widely used in the traditional medicinal system for the treatment of a variety of diseases. The effect of methanolic extract of T. involucrata was studied in different experimental animal models and it was revealed that the extract possesses significant analgesic and anti-inflammatory activity.
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                Author and article information

                Journal
                Afr J Tradit Complement Altern Med
                Afr J Tradit Complement Altern Med
                AJTCAM
                African Journal of Traditional, Complementary, and Alternative Medicines
                African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (Nigeria )
                0189-6016
                2505-0044
                2017
                01 March 2017
                : 14
                : 3
                : 105-112
                Affiliations
                [1 ]Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522034, Andra Pradesh, India
                [2 ]Vaccine Immunology Laboratory, Natural Product Chemistry Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India
                [3 ]Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
                Author notes
                Article
                AJTCAM-14-105
                10.21010/ajtcam.v14i3.11
                5412214
                28480421
                9d786689-b89a-4c82-a948-ca3a9221ef1e
                Copyright: © 2017 Afr. J. Traditional Complementary and Alternative Medicines

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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                Article

                euphorbiaceae,tragia involucrata,tragia cannabina,tragia spathulata,tragia plukenetii,tragia benthamii

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