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      Biochemistry of arsenic detoxification.

      Febs Letters

      metabolism, chemistry, Multienzyme Complexes, Molecular Sequence Data, Ion Pumps, genetics, Ion Channels, Inactivation, Metabolic, Humans, Eukaryotic Cells, Biotransformation, Biodegradation, Environmental, Bacteria, Arsenite Transporting ATPases, pharmacokinetics, Arsenic, Aquaporins, Animals, Amino Acid Sequence

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          Abstract

          All living organisms have systems for arsenic detoxification. The common themes are (a) uptake of As(V) in the form of arsenate by phosphate transporters, (b) uptake of As(III) in the form of arsenite by aquaglyceroporins, (c) reduction of As(V) to As(III) by arsenate reductases, and (d) extrusion or sequestration of As(III). While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.

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          12354618

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