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      Biochemistry of arsenic detoxification.

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      FEBS letters
      Elsevier BV

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          Abstract

          All living organisms have systems for arsenic detoxification. The common themes are (a) uptake of As(V) in the form of arsenate by phosphate transporters, (b) uptake of As(III) in the form of arsenite by aquaglyceroporins, (c) reduction of As(V) to As(III) by arsenate reductases, and (d) extrusion or sequestration of As(III). While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.

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          Author and article information

          Journal
          FEBS Lett
          FEBS letters
          Elsevier BV
          0014-5793
          0014-5793
          Oct 02 2002
          : 529
          : 1
          Affiliations
          [1 ] Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 48201, Detroit, MI, USA. brosen@med.wayne.edu
          Article
          S0014579302031861
          10.1016/s0014-5793(02)03186-1
          12354618
          9d9bbaf1-16a5-483b-85b9-b1dfba2225c3
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