+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Pathology of Interstitial Nephritis Induced in Guinea Pigs by Exoantigens

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Histological and immunofluorescent assessment of the kidney, renal core cultures, and determination of circulating antibodies were carried out in Hartley guinea pigs with a selective delayed-type hypersensitivity state (DTH) and acute interstitial nephritis induced and elicitated by exoantigens. The results show that the normal tubule-vascular structure of the kidney, the simplicity of the molecular structure of the exoantigens and the modification of the native form of the exoantigens, when it is presented to the kidney in the elicitation phase of the DTH reaction, are factors which may reduce the cellular response in the normal renal parenchyma. The cytological events over a 48-hour period are not different to those which have been described in DTH reactions in extrarenal tissues. Exoantigens can induce renal lesions evoking an acute interstitial nephritis picture in animals with selective DTH at a time when there are neither circulating antibodies nor deposition of immunoglobulins or infection in the renal parenchyma.

          Related collections

          Author and article information

          S. Karger AG
          03 December 2008
          : 32
          : 2
          : 170-179
          aInstituto de Patología, Escuela de Medicina José María Vargas, Universidad Central de Venezuela, Caracas, Venezuela; bDepartment of Pathology, Guy’s Hospital Medical School, University of London, England
          182839 Nephron 1982;32:170–179
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Original Paper


          Comment on this article