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      Pathology of Interstitial Nephritis Induced in Guinea Pigs by Exoantigens

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          Abstract

          Histological and immunofluorescent assessment of the kidney, renal core cultures, and determination of circulating antibodies were carried out in Hartley guinea pigs with a selective delayed-type hypersensitivity state (DTH) and acute interstitial nephritis induced and elicitated by exoantigens. The results show that the normal tubule-vascular structure of the kidney, the simplicity of the molecular structure of the exoantigens and the modification of the native form of the exoantigens, when it is presented to the kidney in the elicitation phase of the DTH reaction, are factors which may reduce the cellular response in the normal renal parenchyma. The cytological events over a 48-hour period are not different to those which have been described in DTH reactions in extrarenal tissues. Exoantigens can induce renal lesions evoking an acute interstitial nephritis picture in animals with selective DTH at a time when there are neither circulating antibodies nor deposition of immunoglobulins or infection in the renal parenchyma.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 32
          : 2
          : 170-179
          Affiliations
          aInstituto de Patología, Escuela de Medicina José María Vargas, Universidad Central de Venezuela, Caracas, Venezuela; bDepartment of Pathology, Guy’s Hospital Medical School, University of London, England
          Article
          182839 Nephron 1982;32:170–179
          10.1159/000182839
          6817153
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Original Paper

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