Recombinant ADAMTS 13 Attenuates Brain Injury After Intracerebral Hemorrhage.

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Abstract

Inflammatory responses and blood-brain barrier (BBB) dysfunction play important roles in brain injury after intracerebral hemorrhage (ICH). The metalloprotease ADAMTS 13 (a disintegrin and metalloprotease with thrombospondin type I motif, member 13) was shown to limit inflammatory responses through its proteolytic effects on von Willebrand factor. In the present study, we addressed the role of ADAMTS 13 after experimental ICH.

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Journal

Journal ID (iso-abbrev): Stroke

Title: Stroke; a journal of cerebral circulation

ISSN (Electronic): 1524-4628

ISSN (Print): 0039-2499

Publication date (Electronic): Sep 2015

Volume: 46

Issue: 9

Affiliations

[1 ] From the State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Collaborative Innovation Center for Brain Science and School of Basic Medical Sciences, Fudan University, Shanghai, China (P.C., H.L., H.X., X.Z., W.X., Y.D., J.X., Y.C., B.-Q.Z.,W.F.); Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fujian, China (P.C.); and Neurologic Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China (Y.Z.).

[2 ] From the State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Collaborative Innovation Center for Brain Science and School of Basic Medical Sciences, Fudan University, Shanghai, China (P.C., H.L., H.X., X.Z., W.X., Y.D., J.X., Y.C., B.-Q.Z.,W.F.); Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fujian, China (P.C.); and Neurologic Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China (Y.Z.). wenyingf@fudan.edu.cn bingqiaoz@fudan.edu.cn.

Article

Publisher Item ID: STROKEAHA.115.009526

DOI: 10.1161/STROKEAHA.115.009526

PubMed ID: 26251246

SO-VID: 9dee95aa-18ab-41f6-87ce-d7ccc5b34652

History

Keywords: ADAMTS 13,blood–brain barrier disruption,edema and brain injury,inflammation,intracerebral hemorrhage

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Keywords: ADAMTS 13, blood–brain barrier disruption, edema and brain injury, inflammation, intracerebral hemorrhage

Recombinant ADAMTS 13 Attenuates Brain Injury After Intracerebral Hemorrhage.

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Abstract

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Nanoparticles to cross the blood-brain barrier (BBB)

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