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      Hereditary cerebellar degenerative disease (cerebellar cortical abiotrophy) in rabbits.

      1 , , ,
      Veterinary pathology
      SAGE Publications

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          Abstract

          A pair of rabbits gave birth to a set of littermates (F1) with symptoms of early-onset ataxia. Microscopic examination revealed cerebellar degenerative disease in 5 of 6 littermates. Light microscopy was used to compare the thickness of each cerebellar layer in affected animals in contrast to a normal control. Affected animals showed narrowing of the molecular layer of the vermis, reduced density of Purkinje cell dendrites and irregular thickness in their branchlets, and reduced density of granular cells and scattered pyknotic cells in the granular layer. Pyknotic cells were apoptotic granular cells, confirmed by positive staining using the TUNEL method. Electron microscopy confirmed the thinning of the molecular layer seen by light microscopy and also showed a reduced number of parallel fibers, which indicate granular cells axons, and a reduced number of synaptic junctions between Purkinje and granular cells. Purkinje cells had electron-dense, irregularly shaped cytoplasm with irregularly shaped nuclei, and some of these cells had a central chromatolysis-like region. These findings support a diagnosis of cerebellar cortical abiotrophy, a hereditary condition that causes nerve function impairment leading to early-onset progressive degeneration of the cerebellar cortex.

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          Author and article information

          Journal
          Vet. Pathol.
          Veterinary pathology
          SAGE Publications
          1544-2217
          0300-9858
          Jul 2012
          : 49
          : 4
          Affiliations
          [1 ] Mitsubishi Chemical Medience Co, Ltd, 14 Sunayama, Kamisu-shi, Ibaraki-ken 314-0255, Japan. Satou.Junko@ms.medience.co.jp
          Article
          0300985811402840
          10.1177/0300985811402840
          21646443
          9e0263e0-f3c3-49ae-9181-e414db5526ba
          History

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