Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

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Abstract

The concept and description of platelet-rich plasma (PRP) started in the field of hematology and is being extensively used in other fields of medicine. Interest in the application of PRP has been increasing in dermatology, such as in tissue regeneration, wound healing, scar revision, skin-rejuvenating effects, and alopecia. PRP is an autologous blood product containing high concentrations of platelets in a small volume of plasma. Different preparations of PRP may lead to different volumes of PRP, platelet concentration, and presence or absence of leukocytes. PRP is being used as a new therapy for some types of non-cicatricial alopecia such as androgenetic alopecia (AGA) and alopecia areata (AA) and, recently, new insights refer to the possibility of action in the field of cicatricial alopecia, like lichen planopillaris (LPP) and frontal fibrosing alopecia (FFA). This article aims to identify the major indications for the application of PRP in the field of hair disorders, including non-cicatricial and cicatricial alopecia.

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Most cited references 53

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Hepatocyte growth factor twenty years on: Much more than a growth factor.

Toshikazu Nakamura, Kunio Matsumoto, Katsuya Sakai … (2010)

Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the method for the cultivation of mature hepatocytes provided an opportunity for the discovery of hepatocyte growth factor (HGF) as a protein that is structurally and functionally different from other growth factors. In 1991, the scatter factor, tumor cytotoxic factor, and 3-D epithelial morphogen were identified as HGF, and Met tyrosine kinase was identified as the receptor for HGF. Thus, the connection of apparently unrelated research projects rapidly enriched the research on HGF in different fields. The HGF-Met pathway plays important roles in the embryonic development of the liver and the placenta, in the migration of myogenic precursor cells, and in epithelial morphogenesis. The use of tissue-specific knockout mice demonstrated that in mature tissues the HGF-Met pathway plays a critical role in tissue protection and regeneration, and in providing less susceptibility to chronic inflammation and fibrosis. In various injury and disease models, HGF promotes cell survival, regeneration of tissues, and suppresses and improves chronic inflammation and fibrosis. Drug development using HGF has been challenging, but extensive preclinical studies to address its therapeutic effects have provided significant results sufficient for the development of HGF as a biological drug in the regeneration-based therapy of diseases. Clinical trials using recombinant human HGF protein, or HGF genes, are in progress for the treatment of diseases. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

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A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

Rubina Alves, Ramon Grimalt (2018)

Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased. It is being used in several different applications as in tissue regeneration, wound healing, scar revision, skin rejuvenating effects, and alopecia. PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. It is obtained from the blood of patients collected before centrifugation. The knowledge of the biology, mechanism of action, and classification of the PRP should help clinicians better understand this new therapy and to easily sort and interpret the data available in the literature regarding PRP. In this review, we try to provide useful information for a better understanding of what should and should not be treated with PRP.

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Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis.

Abdullah Alkhalifah, Adel Alsantali, Eddy Wang … (2010)

Alopecia areata (AA) is an autoimmune disease that presents as nonscarring hair loss, although the exact pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance. Recently, newer clinical variants have been described. The presence of AA is associated with a higher frequency of other autoimmune diseases. Controversially, there may also be increased psychiatric morbidity in patients with AA. Although some AA features are known poor prognostic signs, the course of the disease is unpredictable and the response to treatment can be variable. Part one of this two-part series on AA describes the clinical presentation and the associated histopathologic picture. It also proposes a hypothesis for AA development based on the most recent knowledge of disease pathogenesis. After completing this learning activity, participants should be familiar with the most recent advances in AA pathogenesis, recognize the rare and recently described variants of AA, and be able to distinguish between different histopathologic stages of AA. Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

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Contributors

Rubina Alves:

ORCID: http://orcid.org/0000-0002-9542-8020

rubinaalves.dermatologia@gmail.com

Journal

Journal ID (nlm-ta): Dermatol Ther (Heidelb)

Journal ID (iso-abbrev): Dermatol Ther (Heidelb)

Title: Dermatology and Therapy

Publisher: Springer Healthcare (Cheshire )

ISSN (Print): 2193-8210

ISSN (Electronic): 2190-9172

Publication date (Electronic): 17 June 2020

Publication date PMC-release: 17 June 2020

Publication date Collection: August 2020

Volume: 10

Issue: 4

Pages: 623-633

Affiliations

[1 ]GRID grid.414404.1, Serviço de Dermatologia, , Hospital Central do Funchal, ; Avenida Luís de Camões, nº 57, 9004-514 Funchal, Portugal

[2 ]GRID grid.410675.1, ISNI 0000 0001 2325 3084, Facultat de Medicina i Ciències de la Salut, , Universitat Internacional de Catalunya, ; Josep Trueta, s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain

Author information

Rubina Alves http://orcid.org/0000-0002-9542-8020

Ramon Grimalt http://orcid.org/0000-0001-7204-8626

Article

Publisher ID: 408

DOI: 10.1007/s13555-020-00408-5

PMC ID: 7367994

PubMed ID: 32557337

SO-VID: 9e06c5bd-a63b-4514-83b2-e4b99f5013e1

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Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

History

Date received : 4 December 2019

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ScienceOpen disciplines: Dermatology

Keywords: alopecia,alopecia areata,androgenetic alopecia,central centrifugal cicatricial alopecia,cicatricial alopecia,frontal fibrosing alopecia,lichen planopillaris,non-cicatricial alopecia,platelet-rich plasma

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ScienceOpen disciplines: Dermatology

Keywords: alopecia, alopecia areata, androgenetic alopecia, central centrifugal cicatricial alopecia, cicatricial alopecia, frontal fibrosing alopecia, lichen planopillaris, non-cicatricial alopecia, platelet-rich plasma

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review

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Karger: Dermatology

Most cited references 53

Hepatocyte growth factor twenty years on: Much more than a growth factor.

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis.

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