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      Síndrome de McKittrick-Wheelock. Una causa infrecuente de hipokalemia e injuria renal aguda. Caso clínico Translated title: McKrittick-Wheelock syndrome. Report of one case

      case-report
      ,
      Revista médica de Chile
      Sociedad Médica de Santiago
      Acidosis, Adenoma, Villous, Diarrhea, Hypokalemia, Renal Insufficency

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          Translated abstract

          McKittrick-Wheelock syndrome is caused by chronic water and electrolyte hypersecretion from an intestinal tumor, usually a villous adenoma, located in the rectum or sigmoid. Patients often have dehydration, hypovolemic shock and kidney failure associated with hypokalemia, hyponatremia, hypochloremia and metabolic acidosis. We report a 62-year-old male, suffering chronic diarrhea for eight years who was admitted after a syncope. He had severe hypokalemia, hyponatremia, metabolic acidosis, hypovolemia and acute renal failure. After his metabolic disorders were corrected, a colonoscopy showed a large rectosigmoid tumor with the characteristics of a villous adenoma. During the follow up after the complete tumor resection, the patient has remained asymptomatic.

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          Most cited references12

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          McKittrick-Wheelock syndrome: a rare case report of acute renal failure

          Giant tubular-villous adenoma of the rectum can determine secretory diarrhea, associated with a depleting syndrome of prerenal acute renal failure, hyponatremia, hypokalemia and hypoproteinemia. These symptoms are known as the McKittrick-Wheelock syndrome, and there are about 50 cases reported in literature. We present the case of a 59-year-old woman presented to our emergency department with abdominal pain, prerenal azotemia, and electrolyte disturbances with a background of chronic diarrhea, caused by a giant rectal tumor. Conservative therapy initially improved and normalized renal function, and made surgical resection of the tumor possible.
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            A case of giant rectal villous tumor with severe fluid-electrolyte imbalance treated by laparoscopic low anterior resection

            McKittrick-Wheelock syndrome is a disorder caused by fluid and electrolyte hypersecretion from a colorectal tumor. To present the case of a patient with a giant rectal villous tumor with McKittrick-Wheelock syndrome who was successfully treated with laparoscopic surgery. The case of a 59-year-old man who came to the emergency department with syncope, prerenal azotemia, and electrolyte disturbances with a background of chronic diarrhea is reported. His condition was the result of fluid and electrolyte hypersecretion caused by rectal villotubular adenomas. Laparoscopic low anterior resection and subsequent volume and electrolyte replacement therapy resulted in complete recovery. A microscopic examination revealed multiple, well-differentiated adenocarcinomas arising in villotubular adenomas. Laparoscopic surgical resection is a feasible therapeutic modality for McKittrick-Wheelock syndrome.
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              A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma.

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                rmc
                Revista médica de Chile
                Rev. méd. Chile
                Sociedad Médica de Santiago (Santiago, , Chile )
                0034-9887
                July 2017
                : 145
                : 7
                : 950-953
                Affiliations
                [1] Valparaíso orgnameHospital Carlos Van Buren Chile
                [4] Viña del Mar orgnameHospital Dr. Gustavo Fricke orgdiv1Sección Nefrología Chile
                [3] Viña del Mar orgnameHospital Naval A. Nef. orgdiv1Sección Nefrología Chile
                [2] Viña del Mar Valparaíso orgnameUniversidad de Valparaíso orgdiv1Escuela de Medicina orgdiv2Departamento de Medicina Chile
                Article
                S0034-98872017000700950
                10.4067/s0034-98872017000700950
                9e107273-28dd-4b9d-b3f8-17d9c98d98f1

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 19 June 2017
                : 02 March 2017
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 12, Pages: 4
                Product

                SciELO Chile


                Acidosis,Adenoma, Villous,Diarrhea,Hypokalemia,Renal Insufficency

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