Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial.

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Abstract

Delirium is a postoperative complication that occurs frequently in patients older than 65 years, and presages adverse outcomes. We investigated whether prophylactic low-dose dexmedetomidine, a highly selective α2 adrenoceptor agonist, could safely decrease the incidence of delirium in elderly patients after non-cardiac surgery.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Oct 15 2016

Volume: 388

Issue: 10054

Affiliations

[1 ] Department of Anaesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China.

[2 ] Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China.

[3 ] Department of Anaesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China. Electronic address: wangdongxin@hotmail.com.

[4 ] Department of Biostatistics, Peking University First Hospital, Beijing, China.

[5 ] Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.

[6 ] Section of Anaesthetics, Pain Management and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK. Electronic address: d.ma@imperial.ac.uk.

Article

Publisher Item ID: S0140-6736(16)30580-3

DOI: 10.1016/S0140-6736(16)30580-3

PubMed ID: 27542303

SO-VID: 9e1ebc7b-3388-4422-948f-e37e2a844af7

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