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      Decrease in nerve fibre density in human sigmoid colon circular muscle occurs with growth but not aging.

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          Abstract

          Studies in animals suggest that enteric neurons decrease in density or number with increasing age. Neurons containing nitric oxide (NO), vasoactive intestinal peptide (VIP) and Substance P (SP) have been implicated. In human large intestine, NO-utilizing neurons decrease during childhood or early adulthood but it is not known if the innervation of the muscle changes. This study examined the density of nerve fibres containing these transmitters in sigmoid colon circular muscle from children and adults.

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          Author and article information

          Journal
          Neurogastroenterol. Motil.
          Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
          Wiley
          1365-2982
          1350-1925
          Apr 2010
          : 22
          : 4
          Affiliations
          [1 ] Department of General Surgery, Royal Children's Hospital, Melbourne, Australia. bridget.southwell@mcri.edu.au
          Article
          NMO1423
          10.1111/j.1365-2982.2009.01423.x
          19840272
          9e25c4de-d825-4fc1-b6b0-47a315401ad0
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