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      Visible-light optical coherence tomography: a review

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract.

          Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality, providing new capabilities in both anatomical and functional imaging of biological tissue. It relies on visible light illumination, whereas most commercial and investigational OCTs use near-infrared light. As a result, vis-OCT requires different considerations in engineering design and implementation but brings unique potential benefits to both fundamental research and clinical care of several diseases. Here, we intend to provide a summary of the development of vis-OCT and its demonstrated applications. We also provide perspectives on future technology improvement and applications.

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          Optical coherence tomography - principles and applications

          A Fercher, W Drexler, C K Hitzenberger … (2003)
          Article 0 comments Cited 211 times – based on 0 reviews     Review now
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            Fundus autofluorescence imaging: review and perspectives.

            Frank G. Holz, Richard Spaide, Steffen Schmitz-Valckenberg … (2008)
            Fundus autofluorescence (FAF) imaging is a novel imaging method that allows topographic mapping of lipofuscin distribution in the retinal pigment epithelium cell monolayer as well as of other fluorophores that may occur with disease in the outer retina and the subneurosensory space. Excessive accumulation of lipofuscin granules in the lysosomal compartment of retinal pigment epithelium cells represents a common downstream pathogenetic pathway in various hereditary and complex retinal diseases, including age-related macular degeneration. FAF imaging has been shown to be useful with regard to understanding of pathophysiologic mechanisms, diagnostics, phenotype-genotype correlation, identification of predictive markers for disease progression, and monitoring of novel therapies. FAF imaging gives information above and beyond that obtained by conventional imaging methods, such as fundus photography, fluorescein angiography, and optical coherence tomography. Its clinical value coupled with its simple, efficient, and noninvasive nature is increasingly appreciated. This review summarizes basic principles and FAF findings in various retinal diseases.
            Article 0 comments Cited 134 times – based on 0 reviews     Review now
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              Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography.

              Matt Van Camp, E. J. Milner-Gulland, Kimberly J. Nelson … (1997)
              Using a low-coherence Michelson interferometer, we measure two-dimensional images of optical birefringence in bovine tendon as a function of depth. Polarization-sensitive detection of the signal formed by interference of backscattered light from the sample and a mirror in the reference arm give the optical phase delay between light that is propagating along the fast and slow axes of the birefringent tendon. Images showing the change in birefringence in response to laser irradiation are presented. The technique permits rapid noncontact investigation of tissue structural properties through two-dimensional imaging of birefringence.
              Article 0 comments Cited 115 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Biomed Opt
                Journal ID (iso-abbrev): J Biomed Opt
                Journal ID (coden): JBOPFO
                Journal ID (publisher-id): JBO
                Title: Journal of Biomedical Optics
                Publisher: Society of Photo-Optical Instrumentation Engineers
                ISSN (Print): 1083-3668
                ISSN (Electronic): 1560-2281
                Publication date (Electronic): 7 December 2017
                Publication date (Print): December 2017
                Volume: 22
                Issue: 12
                Electronic Location Identifier: 121707
                Affiliations
                [a ]Northwestern University , Department of Biomedical Engineering, Evanston, Illinois, United States
                [b ]Northwestern University , Department of Ophthalmology, Chicago, Illinois, United States
                Author notes
                [* ]Address all correspondence to: Hao F. Zhang, E-mail: hfzhang@ 123456northwestern.edu
                Article
                Publisher-manuscript ID: JBO-170597SSVR Publisher ID: 170597SSVR
                DOI: 10.1117/1.JBO.22.12.121707
                PMC ID: 5745673
                PubMed ID: 29218923
                SO-VID: 9e3ec942-4ec8-4384-86fb-13665f3bca4b
                Copyright © © The Authors.
                License:

                Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

                History
                Date received : 12 September 2017
                Date accepted : 13 November 2017
                Page count
                Figures: 7, Tables: 1, References: 96, Pages: 14
                Funding
                Funded by: National Institutes of Health (NIH) http://dx.doi.org/10.13039/100000002
                Award ID: DP3DK108248
                Award ID: R24EY022883
                Award ID: R01EY026078
                Award ID: R43EY026466
                Award ID: R21EY027502
                Categories
                Subject: Special Section on 25 years of OCT
                Subject: Paper
                Custom metadata
                running-head Shu, Beckmann, and Zhang: Visible-light optical coherence tomography: a review

                ScienceOpen disciplines: Biomedical engineering
                Keywords: optical coherence tomography,retinal imaging,metabolic rate of oxygen,hemodynamics,brain imaging,spectroscopic analysis
                Data availability:
                ScienceOpen disciplines: Biomedical engineering
                Keywords: optical coherence tomography, retinal imaging, metabolic rate of oxygen, hemodynamics, brain imaging, spectroscopic analysis

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