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      The neighbor-joining method: a new method for reconstructing phylogenetic trees.

      1 ,
      Molecular biology and evolution
      Oxford University Press (OUP)

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          Abstract

          A new method called the neighbor-joining method is proposed for reconstructing phylogenetic trees from evolutionary distance data. The principle of this method is to find pairs of operational taxonomic units (OTUs [= neighbors]) that minimize the total branch length at each stage of clustering of OTUs starting with a starlike tree. The branch lengths as well as the topology of a parsimonious tree can quickly be obtained by using this method. Using computer simulation, we studied the efficiency of this method in obtaining the correct unrooted tree in comparison with that of five other tree-making methods: the unweighted pair group method of analysis, Farris's method, Sattath and Tversky's method, Li's method, and Tateno et al.'s modified Farris method. The new, neighbor-joining method and Sattath and Tversky's method are shown to be generally better than the other methods.

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          Author and article information

          Journal
          Mol Biol Evol
          Molecular biology and evolution
          Oxford University Press (OUP)
          0737-4038
          0737-4038
          Jul 1987
          : 4
          : 4
          Affiliations
          [1 ] Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225.
          Article
          10.1093/oxfordjournals.molbev.a040454
          3447015
          9e582885-b8dd-4c36-88f7-689ac7d31b80
          History

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