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      Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.

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          Abstract

          Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome treatment of cells. We report here that the noninvasive Gram-negative pathogen Helicobacter pylori was recognized by epithelial cells via Nod1, an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan. Nod1 detection of H. pylori depended on the delivery of peptidoglycan to host cells by a bacterial type IV secretion system, encoded by the H. pylori cag pathogenicity island. Consistent with involvement of Nod1 in host defense, Nod1-deficient mice were more susceptible to infection by cag pathogenicity island-positive H. pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens.

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          Author and article information

          Journal
          Nat Immunol
          Nature immunology
          Springer Science and Business Media LLC
          1529-2908
          1529-2908
          Nov 2004
          : 5
          : 11
          Affiliations
          [1 ] Groupe d'Immunité Innée et Signalisation, Institut National de la Santé et de la Recherche Médicale U389, Institut Pasteur, Paris, France.
          Article
          ni1131
          10.1038/ni1131
          15489856
          9e6181e1-2115-420a-9412-cb2e078b9a68
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