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Rapid measurement of serum water to assess pseudohyponatremia.

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Clinical chemistry

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      Abstract

      Pseudohyponatremia is caused by an increased serum protein or lipid concentration producing a "space-occupying lesion" in serum water. Its presence and magnitude must be assessed in hyponatremic patients with, for example, paraproteinemia or hyperlipemic diabetic coma. In the absence of a direct-reading ion-selective electrode system, a method for measuring the water content of serum is required. We describe two rapid methods for measuring the diffusible water of serum: osmometry before and after dilution and chloride measurement before and after ultrafiltration. Either of these methods allows the true sodium status of a patient's serum to be determined.

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      Journal
      Clin. Chem.
      Clinical chemistry
      0009-9147
      0009-9147
      Jun 1986
      : 32
      : 6
      3708823

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