The relationship between iron deficiency anemia and simple febrile convulsion in children

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Abstract

Background:

Simple febrile convulsion is the most common disease of the nervous system in children. There are hypotheses that iron deficiency may affect febrile convulsion and the threshold of neuron excitation.

Aims:

This study was conducted with the objective of finding the effects of iron deficiency anemia on simple febrile convulsion episodes.

Settings and Design:

The study was conducted at AmirKabir Hospital of Arak Medical Sciences University, Arak, Iran. This is a case-control study.

Materials and Methods:

In this study, 382 children who were selected according to our inclusion and exclusion factors, were divided into two groups of case (febrile convulsion) and control (other factors causing fever) by their cause of hospitalization. After fever subsided, 5 ml blood sample was taken from each child and complete blood count and iron profile tests were performed.

Statistical Analysis:

The results were interpreted using descriptive statistics and independent t-test. Results: The prevalence of anemia in the group with febrile convulsion was significantly less than that in the control group: 22.5% of the children in the group with febrile convulsion and 34% in the control group exhibited anemia ( P < 0.001). Moreover, the group with febrile convulsion had significantly higher blood indices, such as Hb, Hct, MCV, MCH, and MCHC, compared to the control group ( P < 0.001).

Conclusions:

Iron deficiency can prevent febrile convulsion in children and probably increases the threshold of neuron excitation in fever.

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Most cited references 22

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Iron deficiency alters brain development and functioning.

John Beard (2003)

Iron deficiency anemia in early life is related to altered behavioral and neural development. Studies in human infants suggest that this is an irreversible effect that may be related to changes in chemistry of neurotransmitters, organization and morphology of neuronal networks, and neurobiology of myelination. The acquisition of iron by the brain is an age-related and brain-region-dependent process with tightly controlled rates of movement of iron across the blood-brain barrier. Dopamine receptors and transporters are altered as are behaviors related to this neurotransmitter. The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology.

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Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures.

(2008)

Febrile seizures are the most common seizure disorder in childhood, affecting 2% to 5% of children between the ages of 6 and 60 months. Simple febrile seizures are defined as brief (<15-minute) generalized seizures that occur once during a 24-hour period in a febrile child who does not have an intracranial infection, metabolic disturbance, or history of afebrile seizures. This guideline (a revision of the 1999 American Academy of Pediatrics practice parameter [now termed clinical practice guideline] "The Long-term Treatment of the Child With Simple Febrile Seizures") addresses the risks and benefits of both continuous and intermittent anticonvulsant therapy as well as the use of antipyretics in children with simple febrile seizures. It is designed to assist pediatricians by providing an analytic framework for decisions regarding possible therapeutic interventions in this patient population. It is not intended to replace clinical judgment or to establish a protocol for all patients with this disorder. Rarely will these guidelines be the only approach to this problem.

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Classifying recommendations for clinical practice guidelines.

(2004)

Clinical practice guidelines are intended to improve the quality of clinical care by reducing inappropriate variations, producing optimal outcomes for patients, minimizing harm, and promoting cost-effective practices. This statement proposes an explicit classification of recommendations for clinical practice guidelines of the American Academy of Pediatrics (AAP) to promote communication among guideline developers, implementers, and other users of guideline knowledge, to improve consistency, and to facilitate user understanding. The statement describes 3 sequential activities in developing evidence-based clinical practice guidelines and related policies: 1) determination of the aggregate evidence quality in support of a proposed recommendation; 2) evaluation of the anticipated balance between benefits and harms when the recommendation is carried out; and 3) designation of recommendation strength. An individual policy can be reported as a "strong recommendation," "recommendation," "option," or "no recommendation." Use of this classification is intended to improve consistency and increase the transparency of the guideline-development process, facilitate understanding of AAP clinical practice guidelines, and enhance both the utility and credibility of AAP clinical practice guidelines.

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Author and article information

Journal

Journal ID (nlm-ta): J Pediatr Neurosci

Journal ID (iso-abbrev): J Pediatr Neurosci

Journal ID (publisher-id): JPN

Title: Journal of Pediatric Neurosciences

Publisher: Medknow Publications & Media Pvt Ltd (India )

ISSN (Print): 1817-1745

ISSN (Electronic): 1998-3948

Publication date (Print): May-Aug 2014

Volume: 9

Issue: 2

Pages: 110-114

Affiliations

[1]Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran

[1 ]Department of Biostatistics and Epidemiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran

[2 ]Department of Medical student, Students Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran

Author notes

Address for correspondence: Dr. Mojtaba Sharafkhah, Basij Square, Arak University of Medical Sciences, Arak, Iran. E-mail: sharafkhah@ 123456arakmu.ac.ir

Article

Publisher ID: JPN-9-110

DOI: 10.4103/1817-1745.139276

PMC ID: 4166829

PubMed ID: 25250062

SO-VID: 9e6d82cd-45e8-49df-94fa-fd314fae0260

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The relationship between iron deficiency anemia and simple febrile convulsion in children

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Abstract

Background:

Aims:

Settings and Design:

Materials and Methods:

Statistical Analysis:

Conclusions:

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The Dynamic Brain

Most cited references 22

Iron deficiency alters brain development and functioning.

Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures.

Classifying recommendations for clinical practice guidelines.

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