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      Serum Ferritin in Haemodialysis Patients: Role of Blood Transfusions and Haemochromatosis Alleles’ HLA A3, B7 and B14

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          Abstract

          In 48 patients on maintenance haemodialysis (HD), serum ferritin (SF) levels were measured and compared with ‘haemochromatosis alleles’, (HA), HLA A3, B7 and B14. A positive correlation was found between high SF levels and the presence of HA. When patients who had received 10 or fewer blood transfusions were studied, it was observed that this correlation did not exist, but it was evident, however, in patients who had received more than 10 blood transfusions. After 14 months in which blood transfusions were restricted, no significant difference in SF was observed between HA carriers and the rest. Our findings suggest that repeated blood transfusions can cause high SF in HD patients, especially in those with HLA A3, B7 or B14 antigens. Among our patients, restriction of blood transfusions seems sufficient to decrease high SF levels.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          03 December 2008
          : 36
          : 2
          : 106-110
          Affiliations
          Division of Nephrology, Department of Internal Medicine, C.S. Ntra. Sra. de Covadonga, Oviedo, Spain
          Article
          183127 Nephron 1984;36:106–110
          10.1159/000183127
          6607419
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 5
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          Original Paper

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