Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
8
February
2018
Publication date Collection: 2018
Volume: 13
Issue: 2
Electronic Location Identifier: e0192722
Affiliations
[1
]
Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, United
States of America
[2
]
EpigenDx, Inc., Hopkinton, MA, United States of America
[3
]
Harvard Medical School, Boston, MA, United States of America
University of Perugia, ITALY
Author notes
Competing Interests: The commercial affiliation of MP and LY with EpigenDx does not alter our adherence
to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-17-31204
DOI: 10.1371/journal.pone.0192722
PMC ID: 5805350
PubMed ID: 29420656
SO-VID: 9ea9f4cb-e2a4-4ca2-876a-e1812723b05d
Copyright © © 2018 Owa et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01ES023316
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9434-7835
Toshi Shioda
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R21ES024861
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9434-7835
Toshi Shioda
This study was supported by NIEHS/NIH grants R01ES023316 and R21ES024861 to TS. The
NIEHS/NIH had no role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript. MP and LY are affiliated with EpigenDx, Inc., a
for-profit company specialized in DNA bisulfite pyrosequencing and methylation analysis
(MP, Scientific Director; LY, President). MP and LY played supportive roles in study
design and preparation of the manuscript. MP was also involved in data collection
and analysis. EpigenDx provided financial support to MP and LY in the form of salaries.
Costs of research performed by and at EpigenDx were paid by TS. CO and TS are affiliated
with Massachusetts General Hospital Center for Caner Research, a non-profit research
organization. TS is also affiliated with Harvard Medical School (Associate Professor
of Medicine). CO and TS are supported by the abovementioned NIEHS/NIH grants for salaries
and research expenses. No financial support, in any forms, was provided from EpigenDx
to CO or TS. CO was involved in data collection and analysis, and manuscript preparation.
TS played primary roles in study design and preparation of the manuscript. TS was
exclusively responsible for decisions of contents to be published without being influenced
by EpigenDx.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Chromosome biology
Subject:
Chromatin
Subject:
Chromatin modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Epigenetics
Subject:
Chromatin
Subject:
Chromatin modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Chromatin
Subject:
Chromatin modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
DNA
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
DNA
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Epigenetics
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
DNA
Subject:
Forms of DNA
Subject:
Mitochondrial DNA
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
DNA
Subject:
Forms of DNA
Subject:
Mitochondrial DNA
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Reactions
Subject:
Methylation
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Nucleotides
Subject:
Cytosine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Pyrimidines
Subject:
Cytosine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Pyrimidines
Subject:
Cytosine
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Molecular biology techniques
Subject:
Cloning
Subject:
DNA cloning
Subject:
Shotgun Sequencing
Subject:
Research and analysis methods
Subject:
Molecular biology techniques
Subject:
Cloning
Subject:
DNA cloning
Subject:
Shotgun Sequencing
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Sequencing Techniques
Subject:
Shotgun Sequencing
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Sequencing Techniques
Subject:
Shotgun Sequencing
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Research and analysis methods
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Gene Sequencing
Subject:
Research and analysis methods
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Gene Sequencing
