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      Effect of Intracerebroventricular Clonidine on Serum Corticosterone Levels in Rats

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          In conscious, nonstressed rats clonidine given intracerebroventricularly (i.c.v.) increased the pituitary-adrenocortical response evaluated indirectly from corticosterone concentration. The maximum significant increase occurred 60 min after a dose of 10 µg. The α<sub>2</sub>-adrenoceptor antagonist yohimbine given alone i.c.v. in low doses (0.05–1 µg) had no effect on plasma corticosterone levels, but at higher doses (5 and 10 µg) it produced a significant rise in these levels. Phenoxybenzamine (0.05-10 µg, i.c.v.) caused a dose-related increase in corticosterone secretion. Pretreatment of rats with yohimbine considerably antagonized (up to 70%) the increase of corticosterone response induced by clonidine. Phenoxybenzamine failed to alter this effect. The depletion of brain catecholamines by α-methyl- p-tyrosine caused an increase in serum corticosterone concentration. The rise was suppressed by clonidine (10 µg, i.c.v.), and this suppression was antagonized in part by pretreatment with yohimbine. These data support the concept of the noradrenergic inhibition of ACTH secretion in rats. It seems likely that clonidine injected i.c.v. induces stimulation of corticosterone through the activation of presynaptic α<sub>2</sub>-adrenoceptors and inhibition of noradrenaline release. The clonidine induced inhibition of corticosterone after α-methyl- p-tyrosine seems to be mediated by α-adrenoceptors located postsynaptically.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 20
          : 2
          : 116-123
          Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland
          179983 Horm Res 1984;20:116–123
          © 1984 S. Karger AG, Basel

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          Pages: 8


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