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      Measuring the administered dose of particles on the facial mucosa of a realistic human model

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          Abstract

          Exposure to particulate contaminants can cause serious adverse health effects. Deposition on the facial mucosa is an important path of exposure, but it is difficult to conduct direct dose measurement on real human subjects. In this study, we propose an in vitro method to assess the administered doses of micron-sized particles on the eyes and lips in which computed tomographic scanning and three-dimensional printing were used to create a model that includes a face, oropharynx, trachea, the first five generations of bronchi, and lung volume. This realistic model of a face and airway was exposed to monodispersed fluorescent particles released from an incoming jet. The administered dose of particles deposited upon the eyes and lips, as quantified by fluorescence intensity, was determined via a standard wiping protocol. The results show that, in this scenario, the administered doses normalized by source were 2.15%, 1.02%, 0.88%, 2.13%, and 1.55% for 0.6-, 1.0-, 2.0-, 3.0-, and 5.0-µm particles, respectively. The administered dose of large particles on the mucosa within a given exposure time has great significance. Moreover, the lips suffer a much greater risk of exposure than the eyes and account for more than 80% of total facial mucosa deposition. Our study provides a fast and economical method to assess the administered dose on the facial mucosa on an individual basis.

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          Author and article information

          Journal
          Indoor Air
          Indoor Air
          Wiley
          0905-6947
          1600-0668
          October 21 2019
          January 2020
          November 06 2019
          January 2020
          : 30
          : 1
          : 108-116
          Affiliations
          [1 ]Department of Building Science School of Architecture Tsinghua University Beijing China
          [2 ]Université Paris‐Est CERTES (EA 3481) UPEC Créteil France
          [3 ]State Key laboratory of Green Building in Western China Xi’an University of Architecture and Technology Xi’an China
          [4 ]Department of Civil Engineering Aalborg University Aalborg Denmark
          [5 ]Department of Respiratory Diseases Aalborg University Hospital Aalborg Denmark
          [6 ]The Clinical Institute Aalborg University Aalborg Denmark
          [7 ]School of Building Services Science and Engineering Xi’an University of Architecture and Technology Xi’an China
          [8 ]Department of Mechanical Engineering, Biomanufacturing Center Tsinghua University Beijing China
          Article
          10.1111/ina.12612
          31608493
          9ed0a857-9048-453c-a097-b5f1451bab92
          © 2020

          http://onlinelibrary.wiley.com/termsAndConditions#vor

          http://doi.wiley.com/10.1002/tdm_license_1.1

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