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      Practical considerations for volumetric wear analysis of explanted hip arthroplasties

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          Abstract

          Objectives

          Wear debris released from bearing surfaces has been shown to provoke negative immune responses in the recipient. Excessive wear has been linked to early failure of prostheses. Analysis using coordinate measuring machines (CMMs) can provide estimates of total volumetric material loss of explanted prostheses and can help to understand device failure. The accuracy of volumetric testing has been debated, with some investigators stating that only protocols involving hundreds of thousands of measurement points are sufficient. We looked to examine this assumption and to apply the findings to the clinical arena.

          Methods

          We examined the effects on the calculated material loss from a ceramic femoral head when different CMM scanning parameters were used. Calculated wear volumes were compared with gold standard gravimetric tests in a blinded study.

          Results

          Various scanning parameters including point pitch, maximum point to point distance, the number of scanning contours or the total number of points had no clinically relevant effect on volumetric wear calculations. Gravimetric testing showed that material loss can be calculated to provide clinically relevant degrees of accuracy.

          Conclusions

          Prosthetic surfaces can be analysed accurately and rapidly with currently available technologies. Given these results, we believe that routine analysis of explanted hip components would be a feasible and logical extension to National Joint Registries.

          Cite this article: Bone Joint Res 2014;3:60–8.

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          Most cited references15

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          A literature review of the association between wear rate and osteolysis in total hip arthroplasty.

          The establishment of a polyethylene wear rate threshold for the development of osteolysis at the hip would allow surgeons to identify patients at risk for osteolysis and to implement selective, more frequent follow-up. We reviewed publications that met certain criteria for wear and osteolysis measurement. Based on this review, the incidence of osteolysis increases as the rate of wear increases. The literature indicates that osteolysis rarely is observed at a wear rate of <0.1 mm/y. We suggest that a practical wear rate threshold of 0.05 mm/y would eliminate osteolysis. This wear threshold suggests that the new cross-linked polyethylenes would reduce osteolysis, provided that in vivo wear rates mirror those observed in vitro. To facilitate future comparison of published data, we suggest that longitudinal wear studies adopt consistent edge detection-based wear measurement techniques and uniform osteolytic lesion classification and measurement schema. Copyright 2002, Elsevier Science (USA). All rights reserved.
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            Taper junction failure in large-diameter metal-on-metal bearings

            Objectives An ongoing prospective study to investigate failing metal-on-metal hip prostheses was commenced at our centre in 2008. We report on the results of the analysis of the first consecutive 126 failed mated total hip prostheses from a single manufacturer. Methods Analysis was carried out using highly accurate coordinate measuring to calculate volumetric and linear rates of the articular bearing surfaces and also the surfaces of the taper junctions. The relationship between taper wear rates and a number of variables, including bearing diameter and orientation of the acetabular component, was investigated. Results The measured rates of wear and distribution of material loss from the taper surfaces appeared to show that the primary factor leading to taper failure is the increased lever arm acting on this junction in contemporary large-diameter metal-on-metal hip replacements. Conclusions Our analysis suggests that varus stems, laterally engaging taper systems and larger head diameters all contribute to taper failure.
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              Blood metal ion testing is an effective screening tool to identify poorly performing metal-on-metal bearing surfaces

              Objectives The aims of this piece of work were to: 1) record the background concentrations of blood chromium (Cr) and cobalt (Co) concentrations in a large group of subjects; 2) to compare blood/serum Cr and Co concentrations with retrieved metal-on-metal (MoM) hip resurfacings; 3) to examine the distribution of Co and Cr in the serum and whole blood of patients with MoM hip arthroplasties; and 4) to further understand the partitioning of metal ions between the serum and whole blood fractions. Methods A total of 3042 blood samples donated to the local transfusion centre were analysed to record Co and Cr concentrations. Also, 91 hip resurfacing devices from patients who had given pre-revision blood/serum samples for metal ion analysis underwent volumetric wear assessment using a coordinate measuring machine. Linear regression analysis was carried out and receiver operating characteristic curves were constructed to assess the reliability of metal ions to identify abnormally wearing implants. The relationship between serum and whole blood concentrations of Cr and Co in 1048 patients was analysed using Bland-Altman charts. This relationship was further investigated in an in vitro study during which human blood was spiked with trivalent and hexavalent Cr, the serum then separated and the fractions analysed. Results Only one patient in the transfusion group was found to have a blood Co > 2 µg/l. Blood/Serum Cr and Co concentrations were reliable indicators of abnormal wear. Blood Co appeared to be the most useful clinical test, with a concentration of 4.5 µg/l showing sensitivity and specificity for the detection of abnormal wear of 94% and 95%, respectively. Generated metal ions tended to fill the serum compartment preferentially in vivo and this was replicated in the in vitro study when blood was spiked with trivalent Cr and bivalent Co. Conclusions Blood/serum metal ion concentrations are reliable indicators of abnormal wear processes. Important differences exist however between elements and the blood fraction under study. Future guidelines must take these differences into account.
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                Author and article information

                Contributors
                Role: Director, PXD Ltd URI : http://orthodox.boneandjoint.org.uk/viewprofileinfo.aspx?authorid=1001142
                Role: PhD student URI : http://orthodox.boneandjoint.org.uk/viewprofileinfo.aspx?authorid=1004461
                Role: Consultant Orthopaedic Surgeon URI : http://orthodox.boneandjoint.org.uk/viewprofileinfo.aspx?authorid=1002114
                Role: Professor of Orthopaedic Surgery URI : http://orthodox.boneandjoint.org.uk/viewprofileinfo.aspx?authorid=1001063
                Role: Professor of Orthopaedic Engineering
                Role: Consultant Orthopaedic Surgeon
                Role: Consultant Orthopaedic Surgeon
                Role: Lecturer
                Journal
                Bone Joint Res
                Bone Joint Res
                Bone & Joint Research
                British Editorial Society of Bone and Joint Surgery
                2046-3758
                2046-3758
                March 2014
                01 March 2014
                : 3
                : 3
                : 60-68
                Affiliations
                [1 ]North Tees Explant Centre (NTEC), Farndale House, University Hospital of North Tees, TS19 8PE, UK.
                [2 ]Newcastle University, Stephenson Building, NE1 7RU, UK.
                [3 ]Freeman Hospital, Freeman Road, Newcastle Upon Tyne, UK.
                [4 ]Freeman Hospital and Newcastle University, Freeman Road, Newcastle Upon Tyne, UK.
                [5 ]University Hospital of North Tees, Farndale House, TS19 8PE, UK.
                [6 ]Glasgow Southern General Hospital, 1345 Govan Rd, Glasgow, Lanarkshire G51 4TF, UK.
                [7 ]California Polytechnic State University, Biomedical and General Engineering, San Luis Obispo 93407, USA.
                Author notes
                Correspondence should be sent to Mr D. J. Langton; e-mail: djlangton22@ 123456doctors.org.uk
                Article
                2000249
                10.1302/2046-3758.33.2000249
                4182907
                24627327
                9ef155ae-3446-44b4-a701-05b4a7df39c2
                ©2014 The British Editorial Society of Bone & Joint Surgery

                ©2014 The British Editorial Society of Bone & Joint Surgery. This is an open-access article distributed under the terms of the Creative Commons Attributions licence, which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.

                History
                : 29 October 2013
                : 14 January 2014
                Funding
                D. J. Langton is director of PXD. PXD has received money though medicolegal work concerning failed metal-on-metal hips; as has A. V. F. Nargol. Newcastle University also receives money through medicoloegal litigation on the same subject. R. P. Sidaginamale has received a consulting fee from PXD medical in the last 36 months.
                Categories
                Arthroplasty
                Hip
                Arthroplasty
                Wear Debris
                Coordinate Measuring Machine
                Volumetric Wear
                Metal Ions
                Custom metadata
                1.0
                $2.00
                North Tees Explant Centre, Farndale House, University Hospital of North Tees, United Kingdom
                Research
                One of the authors of the paper, (which is a focus of the methods and discussion in this paper (P. Bills) was a paid defence witness for DePuy in their metal-on-metal litigation.

                hip,arthroplasty,wear debris,coordinate measuring machine,volumetric wear,metal ions

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