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      Effects of Estradiol-Induced Lesions of the Arcuate Nucleus on Gonadotropin Release in Response to Preoptic Stimulation in the Rat

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      Neuroendocrinology

      S. Karger AG

      Hypothalamus, Estradiol, Anovulation, Neuropathology, MPOA

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          Abstract

          Female Wistar rats treated with a single subcutaneous injection of 2 mg estradiol valerate (EV) develop gradually progressive, multifocal lesions of the arcuate nucleus. They also exhibit persistent vaginal estrus and endocrine profiles characteristic of animals sustaining anterior hypothalamic deafferentation. In this study, EV-treated females with the arcuate lesions released significantly less LH 1 h following electrochemical stimulation of the medial preoptic area (MPOA) than did normally cycling controls in proestrus. FSH release in response to MPOA stimulation was the same for both groups. As plasma LH concentrations were not significantly different between EV-treated and control animals 1 h after the injection of a potent LHRH analog, the reduced LH response to MPOA stimulation appears to reflect a primarily hypothalamic defect. However, the EV treatment also affected pituitary responsiveness to long-term stimulation as evidenced by reduced LH responses to the LHRH analog after 2 and 3 h. No such differences were seen in the FSH response.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1980
          1980
          26 March 2008
          : 30
          : 3
          : 144-149
          Affiliations
          Departments of Obstetrics and Gynecology, and Anatomy, McGill University School of Medicine, Montreal, Que.
          Article
          122990 Neuroendocrinology 1980;30:144–149
          10.1159/000122990
          6767994
          © 1980 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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