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      Effects of Estradiol-Induced Lesions of the Arcuate Nucleus on Gonadotropin Release in Response to Preoptic Stimulation in the Rat

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      S. Karger AG

      Hypothalamus, Estradiol, Anovulation, Neuropathology, MPOA

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          Female Wistar rats treated with a single subcutaneous injection of 2 mg estradiol valerate (EV) develop gradually progressive, multifocal lesions of the arcuate nucleus. They also exhibit persistent vaginal estrus and endocrine profiles characteristic of animals sustaining anterior hypothalamic deafferentation. In this study, EV-treated females with the arcuate lesions released significantly less LH 1 h following electrochemical stimulation of the medial preoptic area (MPOA) than did normally cycling controls in proestrus. FSH release in response to MPOA stimulation was the same for both groups. As plasma LH concentrations were not significantly different between EV-treated and control animals 1 h after the injection of a potent LHRH analog, the reduced LH response to MPOA stimulation appears to reflect a primarily hypothalamic defect. However, the EV treatment also affected pituitary responsiveness to long-term stimulation as evidenced by reduced LH responses to the LHRH analog after 2 and 3 h. No such differences were seen in the FSH response.

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          Author and article information

          S. Karger AG
          26 March 2008
          : 30
          : 3
          : 144-149
          Departments of Obstetrics and Gynecology, and Anatomy, McGill University School of Medicine, Montreal, Que.
          122990 Neuroendocrinology 1980;30:144–149
          © 1980 S. Karger AG, Basel

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          Pages: 6
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