+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Corticoadrenal and Adrenergic Overactivity and Hyperlipidemia in Prolonged Emotional Stress

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          A group of 23 Air Force Lieutenant Colonels who attended a long General Staff Course were studied with assays of blood lipid fractions, 11-hydroxycorticoids and excretion of epinephrine, norepinephrine, free 11-hydroxycorticoids, 17-hydroxycorticoids (17-OHCS), dehydroepiandrosterone (DHA) and 17-ketosteroids (17-KS). More or less continuous emotional stress was expected as most of these subjects had familiar responsabilities and the course was extremely competitive, with a large percent of dropouts. This meant, for most of these officers, the end of their careers. Norepinephrine levels were significantly increased and correlated with aggressive behaviour. Significant (p < 0.001) elevations of plasma and urine-free 11-hydroxycorticoíds were registered showing levels in the range found in very stressed subjects. Blood total lipids and cholesterol raised significantly during the course, with levels comparable to those found in hyperlipidemic patients with coronary arteriopathy. The EKG changes were not significant. The possibility that this maintained stressful state might cause a hyperlipoproteinemia and consequent atheromatosis and coronariopathy is discussed.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 3
          : 3
          : 167-174
          D .I.G.I.D. (Ministry of Defense), Department of Endocrinology and Metabolism, Hospital Aeronautico Central, Buenos Aires
          178266 Hormones 1972;3:167–174
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8


          Comment on this article