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      Treatment options for refractory and difficult to treat seizures: focus on vigabatrin

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          Abstract

          Complex partial seizures are often refractory to current pharmacological therapies. These difficult to treat seizures are typically managed using multiple antiepileptic drugs (AEDs). AEDs as a group are frequently associated with significant adverse drug effects, multiple drug interactions, and numerous potential clinical complications due to their individual pharmacokinetic profiles and unique drug properties. Recently, the approval of vigabatrin by the US Food and Drug Administration has necessitated that clinicians re-evaluate these risk-benefit relationships and determine where the drug fits within the treatment scheme for the management of complex partial seizures. This review will facilitate that re-evaluation through a brief review of AEDs used in the treatment of complex partial seizures, followed by a focused discussion on vigabatrin.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2011
          2011
          01 September 2011
          : 7
          : 367-375
          Affiliations
          School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, NE, USA
          Author notes
          Correspondence: Justin A Tolman, School of Pharmacy and Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA, Tel +1 402 280 2915, Fax +1 402 280 1883, Email justintolman@ 123456creighton.edu
          Article
          tcrm-7-367
          10.2147/TCRM.S8519
          3176170
          21941443
          © 2011 Tolman and Faulkner, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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