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      Myocardial Angiogenesis Resulting in Functional Communications with the Left Cavity Induced by Intramyocardial High-Frequency Ablation: Histomorphology of Immediate and Long-Term Effects in Pigs

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          Abstract

          A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). Myocardial channels were found to be highly reproducible and patent in more than two thirds in group A. Channels were replaced by connective tissue during follow-up which contained newly formed small vessels. A functional communication between the left ventricular cavum and newly formed vessels of the channel remnants could be demonstrated in one heart of group C. Thus, intramyocardial HF ablation can be performed with high reproducibility to induce local angiogenesis.

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          Most cited references10

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          Transmyocardial laser revascularisation compared with continued medical therapy for treatment of refractory angina pectoris: a prospective randomised trial

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            Evidence of Vascular Growth Associated With Laser Treatment of Normal Canine Myocardium

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              Transmyocardial laser revascularisation in patients with refractory angina: a randomised controlled trial

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                Author and article information

                Journal
                CRD
                Cardiology
                10.1159/issn.0008-6312
                Cardiology
                S. Karger AG
                0008-6312
                1421-9751
                2003
                February 2003
                24 February 2003
                : 99
                : 1
                : 32-38
                Affiliations
                aGerman Clinic for Diagnostics, Wiesbaden, and bSecond Medical Clinic and cInstitute of Pathology, Johannes Gutenberg University, Mainz, Germany; dBakken Research Center, Maastricht, The Netherlands
                Article
                68450 Cardiology 2003;99:32–38
                10.1159/000068450
                12589120
                9f0e4574-88bf-4798-8fda-449daa06369d
                © 2003 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                : 16 September 2002
                : 05 November 2002
                Page count
                Figures: 3, References: 29, Pages: 7
                Categories
                General Cardiology – Basic Science

                General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
                Myocardial perfusion,High-frequency ablation,Myocardial revascularization

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