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      Myocardial Angiogenesis Resulting in Functional Communications with the Left Cavity Induced by Intramyocardial High-Frequency Ablation: Histomorphology of Immediate and Long-Term Effects in Pigs

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          A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). Myocardial channels were found to be highly reproducible and patent in more than two thirds in group A. Channels were replaced by connective tissue during follow-up which contained newly formed small vessels. A functional communication between the left ventricular cavum and newly formed vessels of the channel remnants could be demonstrated in one heart of group C. Thus, intramyocardial HF ablation can be performed with high reproducibility to induce local angiogenesis.

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          Most cited references 10

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          Transmyocardial laser revascularisation compared with continued medical therapy for treatment of refractory angina pectoris: a prospective randomised trial

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            Transmyocardial laser revascularisation in patients with refractory angina: a randomised controlled trial

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              Evidence of Vascular Growth Associated With Laser Treatment of Normal Canine Myocardium


                Author and article information

                S. Karger AG
                February 2003
                24 February 2003
                : 99
                : 1
                : 32-38
                aGerman Clinic for Diagnostics, Wiesbaden, and bSecond Medical Clinic and cInstitute of Pathology, Johannes Gutenberg University, Mainz, Germany; dBakken Research Center, Maastricht, The Netherlands
                68450 Cardiology 2003;99:32–38
                © 2003 S. Karger AG, Basel

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                Page count
                Figures: 3, References: 29, Pages: 7
                General Cardiology – Basic Science


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