6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

      Proceedings of the National Academy of Sciences of the United States of America
      Alzheimer Disease, genetics, pathology, Amino Acid Sequence, Amyloid beta-Protein Precursor, physiology, Cell Death, Cells, Cultured, Extracellular Space, Humans, Intracellular Signaling Peptides and Proteins, Molecular Sequence Data, Neurons, Peptides, Poly A, Proteins, Superoxide Dismutase

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Abeta amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.

          Related collections

          Author and article information

          Comments

          Comment on this article