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      Renal Function and Mercury Level in Rats with Mercuric Chloride Nephrotoxicity

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      Nephron

      S. Karger AG

      Acute renal failure, Renal Hg++levels, Blood Hg++ levels

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          Abstract

          The levels of Hg++ in different subcellular compartments of rat kidney cortex were determined after a single subcutaneous injection of <sup>203</sup>HgCl<sub>2</sub>, 4.7 mg/kg body weight. By 30 min after injection, cortical Hg<sup>++</sup>level was 46.3 ± 6.8 µg/g protein. A maximal cortical Hg<sup>++·</sup> value of 429 ± 49 µg/g protein was reached 4 h after injection. Hg<sup>++</sup>associated with the brush border membrane showed a progressive increase during the first 15 h after injection, but at each time interval was significantly less than cortical Hg<sup>++</sup> The 45-hour values for cortex and brush border were equivalent. No evidence for the presence in plasma or kidney tissue of free Hg<sup>++</sup> was obtained. Saline loading protected animals against the development of renal failure and resulted in significant lowering of cortical Hg<sup>++</sup> levels without an effect on blood Hg<sup>++</sup> concentrations.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1980
          1980
          02 December 2008
          : 26
          : 1
          : 28-34
          Affiliations
          Division of Nephrology, Department of Medicine, Medical College of Virginia, Richmond, Va.
          Article
          181946 Nephron 1980;26:28–34
          10.1159/000181946
          6446687
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Acute renal failure, Renal Hg++levels, Blood Hg++ levels

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