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      Viscosity Attunes the Adhesion of Bioinspired Low Modulus Polyester Adhesive Sealants to Wet Tissues

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          Abstract

          Clinically used bio-based tissue sealants bring in the risk of animal-borne infections, non-degradability, allergic reactions, tissue compression, tissue necrosis, and poor wet adhesion. Motivated by these unsatisfactory properties of existing tissue sealants, herein, we designed a library of solvent- and initiator-free hydrophobic mussel-inspired degradable tissue adhesives that can stick and seal the epidermis, pericardium, and Glisson's capsule under physiologically relevant wet conditions. By varying the molar ratio of the functional groups, we obtained polyester adhesive sealants with similar surface energy and varying viscosity. The careful examination of the wetting behavior of these polyester adhesive sealants on tissue surfaces showed that the polyester adhesive sealant with lower viscosity has higher intrinsic work of adhesion, which allowed them to adhere to strongly hydrated surfaces such as pericardium and Glisson's capsule. Because of the lower intrinsic work of adhesion, the polyester adhesive sealant with higher viscosity only adhered to the relatively hydrophobic surface (epidermis). The strong wet adhesion to tissue surfaces, cell-compatibility, hydrolytic degradability, and radical scavenging nature of these polyester adhesive sealants make them potential candidates for wound closure procedures.

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          Author and article information

          Journal
          Biomacromolecules
          Biomacromolecules
          American Chemical Society (ACS)
          1525-7797
          1526-4602
          June 04 2019
          June 04 2019
          Article
          10.1021/acs.biomac.9b00383
          31244021
          © 2019
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