Clinically used bio-based tissue sealants bring in the risk of animal-borne infections,
non-degradability, allergic reactions, tissue compression, tissue necrosis, and poor
wet adhesion. Motivated by these unsatisfactory properties of existing tissue sealants,
herein, we designed a library of solvent- and initiator-free hydrophobic mussel-inspired
degradable tissue adhesives that can stick and seal the epidermis, pericardium, and
Glisson's capsule under physiologically relevant wet conditions. By varying the molar
ratio of the functional groups, we obtained polyester adhesive sealants with similar
surface energy and varying viscosity. The careful examination of the wetting behavior
of these polyester adhesive sealants on tissue surfaces showed that the polyester
adhesive sealant with lower viscosity has higher intrinsic work of adhesion, which
allowed them to adhere to strongly hydrated surfaces such as pericardium and Glisson's
capsule. Because of the lower intrinsic work of adhesion, the polyester adhesive sealant
with higher viscosity only adhered to the relatively hydrophobic surface (epidermis).
The strong wet adhesion to tissue surfaces, cell-compatibility, hydrolytic degradability,
and radical scavenging nature of these polyester adhesive sealants make them potential
candidates for wound closure procedures.