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      Emergence and Evolution of the Circadian Rhythm of Melatonin in Children

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          Objective: To assess the age at which the circadian rhythm of melatonin begins. Methods: 55 children, divided into groups from the neonatal period to 24 months of life, were studied. Urine samples were taken from 28 newborn babies to measure 6-sulfatoxymelatonin (aMT6s). Salivary samples were collected from infants (27 cases), to measure melatonin (aMT). aMT was measured by RIA and aMT6s by ELISA using commercial kits. Changes in the levels of aMT6s and aMT were evaluated using the Friedman test and Wilcoxon matched pair test. Results: The group aged 27–41 days showed statistically significant differences in daily aMT6s and aMT concentrations. The highest values were always found between 24.00 and 8.00 h. This day/night difference persisted from 2–3 to 13–24 months of age. Conclusion: The data indicate that the circadian melatonin rhythm appears at the end of the neonatal period and persists thereafter.

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          Most cited references 6

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          Development of melatonin production in infants and the impact of prematurity

           D Kennaway (1992)
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            Daily and seasonal variations in the concentration of melatonin in the human pineal gland

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              Measurement of Urinary Melatonin: A Useful Tool for Monitoring Serum Melatonin after Its Oral Administration

               J. Kovács (2000)

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                20 February 2003
                : 59
                : 2
                : 66-72
                Departments of aPediatrics and bBiochemistry, Cellular Biology and Physiology, University Hospital, University of Valladolid, Spain
                68571 Horm Res 2003;59:66–72
                © 2003 S. Karger AG, Basel

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                Page count
                Figures: 3, Tables: 2, References: 32, Pages: 7
                Original Paper


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