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      Ruthenium-Red-Stained Polyanionic Fixed Charges in Peritoneal Microvessels

      , , ,

      Nephron

      S. Karger AG

      Transperitoneal transport, Anionic sites, Peritoneal dialysis, Ruthenium

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          Abstract

          This study shows that the luminal surface of peritoneal microvascular endothelium, coated pits and coated vesicles are all negatively charged, unlike the limiting membrane of pinocytotic vesicles and transcellular channels. Our findings suggest that these cellular organelles have different functions as well as a different chemical composition. Anionic sites were observed along the subendothelial and subperithelial basal laminae of peritoneal capillaries and post capillary venules, respectively. Electric charge is a new parameter to be considered when analyzing transperitoneal transfer of charged macromolecules.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 47
          : 1
          : 22-28
          Affiliations
          Department of Nephrology and the Kornach Laboratory for Experimental Nephrology, Central Emek Hospital, Afula, Israel
          Article
          184451 Nephron 1987;47:22–28
          10.1159/000184451
          2442635
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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