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      Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

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          Abstract

          A new lignan, tirpitzin A ( 17) together with 20 known compounds ( 116, and 1821) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 721 were isolated from Linaceae family for the first time. The pharmacological activity of the crude extracts was tested using a mouse inflammation model induced by dimethyl benzene. The results demonstrated that the ethyl acetate soluble fraction had anti-inflammatory activity. Moreover, the cytotoxic and anti-inflammatory activities of some compounds were studied. The new compound 17 showed moderate cytotoxic effect against BxPC-3 cell line (IC 50 = 19.51μmol·L −1) and Compound 10 showed significant cytotoxicity against HepG2, HL-60, U87 and BxPC-3 cell lines with IC 50 values in the range 4.2-8.3μmol·L −1. Additionally, Compounds 2, 10, 11, and 13 exhibited potent inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages at the concentration of 50μmol·L −1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 December 2017
          : 15
          : 12
          : 938-943
          Affiliations
          1Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
          Author notes
          *Corresponding author: SHANG Ming-Ying, Tel/Fax: +86-010-8280-2534. E-mail: myshang@ 123456bjmu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30010-4
          10.1016/S1875-5364(18)30010-4
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Key Technology R&D Program “New Drug Innovation” of China
          Award ID: 2013ZX09103002-006
          Award ID: 2013ZX09508104
          This work was supported by the National Key Technology R&D Program “New Drug Innovation” of China (Nos. 2013ZX09103002-006 and 2013ZX09508104).

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