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      In vivo minimally invasive interstitial multi-functional microendoscopy

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          Abstract

          Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200 μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1 μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.

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          Author and article information

          Journal
          Sci Rep
          Sci Rep
          Scientific Reports
          Nature Publishing Group
          2045-2322
          28 May 2013
          2013
          : 3
          Affiliations
          [1 ]Clinical Photonics Lab, School in Advanced Optical Technologies (SAOT) , Erlangen 91052, Germany
          [2 ]Friedrich-Alexander Erlangen-Nuremberg University , Erlangen, 91052, Germany
          [3 ]Multidisciplinary Brain Research Center, Bar-Ilan University , Ramat-Gan 52900, Israel,
          [4 ]Department of Physics, Ryerson University , 350 Victoria Street, Toronto M5B 2K3, Canada
          [5 ]Medical Photonics Engineering Group (MPEG) , Chair of Photonics Technologies, Erlangen 91052, Germany
          [6 ]Faculty of Engineering, Bar-Ilan University , Ramat Gan 52900, Israel
          Author notes
          Article
          srep01805
          10.1038/srep01805
          3664902
          23712369
          Copyright © 2013, Macmillan Publishers Limited. All rights reserved

          This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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