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      Characterization of the Mechanism of Acute Ocular Irritation to YAG Laser Capsulotomy in Rabbits: Effects of Substance P Antagonists, Met-Enkephalin, Tetracaine and Tetrodotoxin


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          This study was undertaken to characterize the mechanism of ocular irritation to YAG laser capsulotomy in rabbits. The blocking agents were administered intravitreally. ( D-Arg<sup>1</sup>, D-Pro<sup>2</sup>, D-Trp<sup>7,9</sup>)-SP, a substance P antagonist, tended to reduce miosis but had no effect on intraocular pressure (IOP). It had less effect on miosis than ( D-Arg<sup>1</sup>, D-Pro<sup>2</sup>, D-Trp<sup>7,9</sup>, Leu<sup>11</sup>-SP another SP antagonist. Met-enkephalin and tetracaine had no effect on miosis or the increase in IOP after YAG laser capsulotomy, whereas tetrodotoxin reduced miosis, but had no clear-cut effect on IOP, or the increase in aqueous humor protein concentration. This indicates an involvement of sensory neurons with release of SP or a closely related peptide in the miotic component part while the increase in IOP and the barrier breakdown probably are dependent mainly on a release of prostaglandins

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          10 December 2009
          : 21
          : 5
          : 360-368
          aResearch Department of Pharmaceutical Company Oy Star Ab, Tampere; bEye Clinic, University Hospital of Oulu, Oulu, Finland
          266900 Ophthalmic Res 1989;21:360–368
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 20 June 1988
          : 19 October 1988
          Page count
          Pages: 9
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Neodymium:YAG laser,Substance P antagonists,Tetrodotoxin,Met-enkephalin,Acute ocular irritation,Tetracaine,Lens capsulotomy,Rabbit


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