Release of Endogenous ATP from Rat Caudal Artery

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Abstract

Electrical field stimulation of the rat caudal artery (0.5-ms pulses at 8 Hz for 3 min) results in the release of norepinephrine (quantified by HPLC-electrochemical detection) and adenyl purines including ATP, ADP and AMP (quantified by HPLC-fluorescence detection). The amount of ATP released from the tissue exceeded the amount of norepinephrine. Because postjunctional α1-adrenoceptor stimulation with methoxamine also causes release of ATP, both neuronal and extraneuronal sites may contribute to the overflow of ATP. Results with the α1-adrenoceptor antagonist prazosin lend support to this notion. Prazosin (10–6 M) completely blocked the release of ATP by methoxamine but only partially reduced the release of ATP by field stimulation.

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Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISBN: 978-3-8055-4604-1

ISBN: 978-3-318-02026-7

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 23 September 2008

Volume: 24

Issue: 3

Pages: 125-127

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Department of Pharmacology, University of Nevada School of Medicine, Reno, Nev., USA

Article

Publisher ID: 158684 Other ID: Blood Vessels 1987;24:125–127

DOI: 10.1159/000158684

SO-VID: 9fac454d-2db2-4dbd-8e6f-87e835c6cf3d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Release of Endogenous ATP from Rat Caudal Artery

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Karger: Cardiovascular System

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