For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
23
views
20
references
 Top references
cited by
42
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      80
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Sodium Iodate Selectively Injuries the Posterior Pole of the Retina in a Dose-Dependent Manner: Morphological and Electrophysiological Study

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Sequential morphological and functional features of retinal damage in mice exposed to different doses (40 vs. 20 mg/kg) of sodium iodate (NaIO 3) were analyzed. Retinal morphology, apoptosis (TUNEL assay), and function (electroretinography; ERG) were examined at several time points after NaIO 3 administration. The higher dose of NaIO 3 caused progressive degeneration of the whole retinal area and total suppression of scotopic and photopic ERG. In contrast, the lower dose induced much less severe degeneration in peripheral part of retina along with a moderate decline of b- and a-wave amplitudes in ERG, corroborating the presence of regions within retina that retain their function. The peak of photoreceptor apoptosis was found on the 3rd day, but the lower dose induced more intense reaction within the central retina than in its peripheral region. In conclusion, these results indicate that peripheral area of the retina reveals better resistance to NaIO 3 injury than its central part.

          Related collections

          Most cited references20

          • Record: found
          • Abstract: not found
          • Article: not found

          The toxic effect of sodium L-glutamate on the inner layers of the retina.

          Ian Newhouse, Brandon Lucas (1957)
          Article 0 comments Cited 125 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration.

            Leila Kheirandish-Gozal, Edward H. Kaplan, B W Row … (2006)
            We characterized changes in the visual behavior of mice in which a loss of the retinal pigment epithelium (RPE) was experimentally induced with intravenous (i.v.) administration of sodium iodate (NaIO3). We compared and correlated these changes with alterations in neural retinal structure and function. RPE loss was induced in 4-6 week old male C57BL/6 mice with an i.v. injection of 1% NaIO3 at three concentrations: 35, 50, or 70 mg/kg. At 1, 3, 7, 14, 21, and 28 days (d) as well as 6 months post injection (PI) a behavioral test was performed in previously trained mice to evaluate visual function. Eye morphology was then assessed for changes in both the RPE and neural retina. NaIO3-induced RPE degeneration was both dose and PI time dependent. Our low dose showed no effects, while our high dose caused the most damage, as did longer PI times at our intermediate dose. Using the intermediate dose, no changes were detectable in either visual behavior or retinal morphology at 1 d PI. However, at 3 d PI visual behavior became abnormal and patchy RPE cell loss was observed. From 7 d PI onward, changes in retinal morphology and visual behavior became more severe. At 6 months PI, no recovery was seen in any of these measures in mice administered the intermediate dose. These results show that NaIO3 dosage and/or time PI can be varied to produce different, yet permanent deficits in retinal morphology and visual function. Thus, this approach should provide a unique system in which the onset and severity of RPE damage, and its consequences can be manipulated. As such, it should be useful in the assessment of rescue or mitigating effects of retinal or stem cell transplantation on visual function.
            Article 0 comments Cited 48 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              RPE destruction causes choriocapillary atrophy.

              V Reppucci, P Henkind, G Korte (1984)
              The authors have obtained evidence that destruction of the retinal pigment epithelium (RPE) causes choriocapillaris (CC) atrophy. The observations led us to hypothesize that the RPE modulates CC structure and function. Rabbits received injections of sodium iodate, which selectively destroyed the RPE. The authors killed the rabbits at various times after iodate and examined the RPE and CC by fluorescein angiography, fundus photography, and light and electron microscopy. Fluorescein angiography and fundus photography revealed a pattern of retinopathy similar to that described by other investigators, eg, blood-retinal barrier breakdown and the patchy nature of the RPE/CC degeneration. One week after injection of iodate, the RPE transformed into a mixture of flattened, depigmented cells and plump, highly pigmented ones lying along Bruch's membrane. The CC appeared normal by light microscopy, but electron microscopy revealed changes indicating CC atrophy: degenerating endothelial cells (EC), EC that appeared normal but had reduced numbers of fenestrae, and pericapillary basal laminae that looped away from the endothelium, as if the latter had shrunk. One month after iodate, patches of Bruch's membrane were devoid of RPE, which was replaced by scar tissue. The CC was markedly atrophic over these patches, having reduced numbers of profiles and smaller lumina in those which remained. The CC appeared normal over areas where RPE remained. Eleven weeks after iodate, the light microscopic picture parallelled that seen 1 month after injection, but the patchy RPE degeneration was more extensive. By electron microscopy, the CC profiles over areas devoid of RPE showed severe atrophy. Degenerating EC were more numerous. EC adjacent to areas of RPE loss had few or no fenestrae. Here, capillaries were encased in dense, collagenous, connective tissue, unlike the CC of normal rabbits. These changes were not seen where the RPE still covered Bruch's membrane. These observations suggest that RPE modulates CC structure and function. The authors propose that a diffusible vascular modulating factor produced by RPE cells does this.
              Article 0 comments Cited 40 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                : annam@sci.pam.szczecin.pl
                : +4891 4661546 , +4891 4661548 , machalin@sci.pam.szczecin.pl
                Journal
                Journal ID (nlm-ta): Neurochem Res
                Title: Neurochemical Research
                Publisher: Springer US (Boston )
                ISSN (Print): 0364-3190
                ISSN (Electronic): 1573-6903
                Publication date (Electronic): 20 August 2010
                Publication date PMC-release: 20 August 2010
                Publication date (Print): November 2010
                Volume: 35
                Issue: 11
                Pages: 1819-1827
                Affiliations
                [1 ]Department of Histology and Embryology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, Poland
                [2 ]Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland
                [3 ]Department of General Pathology, Pomeranian Medical University, Szczecin, Poland
                [4 ]Department of Physiology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, Poland
                Article
                Publisher ID: 248
                DOI: 10.1007/s11064-010-0248-6
                PMC ID: 2957578
                PubMed ID: 20725778
                SO-VID: 9fb8058f-16c0-4a3f-b8a3-17e7497c5450
                Copyright © © The Author(s) 2010
                History
                Date accepted : 10 August 2010
                Categories
                Subject: Original Paper
                Custom metadata
                issue-copyright-statement © Springer Science+Business Media, LLC 2010

                ScienceOpen disciplines: Neurosciences
                Keywords: retinal degeneration,sodium iodate,electroretinogram,apoptosis
                Data availability:
                ScienceOpen disciplines: Neurosciences
                Keywords: retinal degeneration, sodium iodate, electroretinogram, apoptosis

                Comments

                Comment on this article

                scite_

                Similar content80

                See all similar

                Cited by42

                See all cited by

                Most referenced authors122

                See all reference authors