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      Intravenously Infused Substance P Is Unable to Change Basal and TRH-Stimulated PRL Secretion in Normal Men

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          Abstract

          In order to test the possible effects of an intravenous administration of substance P (SP) on basal and TRH-stimulated PRL release, SP was infused alone (0.5 or 1.5 pmol/kg<sup>-1</sup>/min<sup>-1</sup> for 60 min) or after TRH (20 or 400 µg in an i.v. bolus) in 21 normal male subjects. In addition, plasma cortisol levels during SP infusion were measured. In agreement with previous findings, a significant increase in plasma cortisol levels was observed when the higher (1.5pmol/ kg<sup>-1</sup>/min<sup>-1</sup>) but not the lower (0.5 pmol/kg<sup>-1</sup>/min<sup>-1</sup>) amount of SP was given. In contrast, basal and TRH (20 or 400 µg)-induced PRL release were not modified by SP at any tested amount. These data suggest that, in normal men, plasma SP is not involved in the control of PRL release at the anterior pituitary level.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1993
          1993
          03 December 2008
          : 39
          : 1-2
          : 73-76
          Affiliations
          University Clinics of aInternal Medicine, bEndocrinology and cPsychiatry, University of Parma; dEndocrine Unit, Hospital of Codogno; eDivision of Internal Medicine, Hospital of Fidenza; fLaboratory of Biochemistry, Hospital of Guastalla, Italy
          Article
          182699 Horm Res 1993;39:73–76
          10.1159/000182699
          7691703
          9fbea67f-e7e0-4477-b7c5-9ec4b228fe55
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 14 September 1992
          : 05 February 1993
          Page count
          Pages: 4
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Substance P,Prolactin,TRH

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