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      Intravenously Infused Substance P Is Unable to Change Basal and TRH-Stimulated PRL Secretion in Normal Men

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          In order to test the possible effects of an intravenous administration of substance P (SP) on basal and TRH-stimulated PRL release, SP was infused alone (0.5 or 1.5 pmol/kg<sup>-1</sup>/min<sup>-1</sup> for 60 min) or after TRH (20 or 400 µg in an i.v. bolus) in 21 normal male subjects. In addition, plasma cortisol levels during SP infusion were measured. In agreement with previous findings, a significant increase in plasma cortisol levels was observed when the higher (1.5pmol/ kg<sup>-1</sup>/min<sup>-1</sup>) but not the lower (0.5 pmol/kg<sup>-1</sup>/min<sup>-1</sup>) amount of SP was given. In contrast, basal and TRH (20 or 400 µg)-induced PRL release were not modified by SP at any tested amount. These data suggest that, in normal men, plasma SP is not involved in the control of PRL release at the anterior pituitary level.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 39
          : 1-2
          : 73-76
          University Clinics of aInternal Medicine, bEndocrinology and cPsychiatry, University of Parma; dEndocrine Unit, Hospital of Codogno; eDivision of Internal Medicine, Hospital of Fidenza; fLaboratory of Biochemistry, Hospital of Guastalla, Italy
          182699 Horm Res 1993;39:73–76
          © 1993 S. Karger AG, Basel

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          Pages: 4
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