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      Body vectoring technique with Radiesse ® for tightening of the abdomen, thighs, and brachial zone

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          Abstract

          Background

          The objective of this study was to investigate the efficacy, safety, and subject satisfaction of the calcium hydroxylapatite-based dermal filler Radiesse ® in a novel body vectoring technique to correct skin flaccidity in the thighs, abdomen, and brachial zones.

          Methods

          Female subjects with self-evaluated flaccidity scores ≥3 on a 6-point scale (0, no flaccidity; 5, very severe flaccidity) in the zones of interest were included. Radiesse was injected according to predesigned vector maps (3 mL per thigh, 1.5 mL per hemiabdomen or brachial zone). Clinical assessments (skin density and thickness) were made by an independent reviewer at an exact position before and 5 weeks after treatment using a cutometer and an ultrascan. Subjects rated skin flaccidity before and 5 weeks after treatment on the 6-point scale and performed a pinch test to self-assess changes in skin thickness. All adverse events were recorded.

          Results

          Twenty females (aged 28–67 years) were enrolled, contributing 36 treatment zones. Across all zones, 78% of flaccidity measurements improved after treatment. Improvements in skin flaccidity were most common in the thighs (82% of cases). An improvement in skin density versus baseline was observed in the majority across all zones, most frequently in the abdomen (88% of cases). Skin thickness in each zone also improved versus baseline for the majority, most frequently in the thighs (88% of cases). Mean self-assessed flaccidity scores at baseline were 3.6 (thighs), 3.7 (abdomen), and 3.8 (brachial zone), and 2.6, 2.7, and 3.0, respectively, posttreatment. All subjects reported a positive pinch test. In total, 47.0% of subjects had bruising after treatment, which resolved within a week. No serious adverse events were reported.

          Conclusion

          Using this novel technique, Radiesse had notable results on skin flaccidity, density and thickness in the thighs, abdomen, and brachial zones, and was well tolerated.

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          Most cited references17

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          Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler.

          Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers.
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            Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis.

            BACKGROUND Soft-tissue augmentation using calcium hydroxylapatite (CaHA) filler has been shown to be a safe and effective filler agent. A previous study utilizing electron microscopy demonstrated deposition of collagen around filler microspheres with minimal inflammatory response. OBJECTIVE The purpose of this study was to further characterize the expression of collagen in response to injected CaHA filler material using conventional, special, and immunohistochemical (IHC) staining. MATERIALS AND METHODS Five subjects with mild to moderate nasolabial rhytids underwent a single treatment with CaHA filler. Additionally, 0.1 to 0.2 mL of the filler material was injected subdermally into the postauricular area. Six months following the treatment, all subjects underwent biopsy of the treated postauricular area. Biopsies were analyzed using hematoxylin and eosin staining, special staining with picrosirius red (PSR), and IHC staining for collagen Types I and III. RESULTS All subjects completed the study with no complications. Biopsy specimens revealed increased deposition of collagen around the filler material, which was confirmed and further characterized using PSR and IHC staining. CONCLUSION Soft tissue augmentation with CaHA filler leads to long-term deposition of new collagen surrounding filler microspheres, which may contribute to the overall improvement in the appearance of treated rhytids.
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              Structural changes in ageing skin.

              As average life expectancy is increasing, the ageing of skin presents a growing problem for dermatologists. When considering ageing it is important to distinguish between the effects of true biological ageing and environmental factors, such as exposure to sun. Epidermal changes associated with ageing involve the flattening of its underside, a reduction in the number of Langerhans cells and of melanocytes, and a decline in the number of melanosomes synthesized, leading to reduced pigmentation. Dermal changes involve a reduction in the collagenous and elastic fibres, fibroblasts, mast cells and macrophages, and dilation of the lymphatic channels. The number of hair follicles declines with age, but their structure remains unchanged. Ageing does not affect the sebaceous glands, but some changes occur in the exocrine sweat glands.
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                Author and article information

                Journal
                Clin Cosmet Investig Dermatol
                Clin Cosmet Investig Dermatol
                Clinical, Cosmetic and Investigational Dermatology
                Clinical, Cosmetic and Investigational Dermatology
                Dove Medical Press
                1178-7015
                2015
                19 May 2015
                : 8
                : 267-273
                Affiliations
                Médico Estético Cosmetic Medicine, Clinic Novosalud, Madrid, Spain
                Author notes
                Correspondence: Valeria Cogorno Wasylkowski, Clinica Novosalud, Paseo la Castellana 54, 28046, Madrid, Spain, Tel +34 680 124 018, Email valeriacogorno@ 123456gmail.com
                Article
                ccid-8-267
                10.2147/CCID.S75631
                4445588
                9fc4f692-e156-4b30-8439-d355050dd589
                © 2015 Cogorno Wasylkowski. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

                The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Original Research

                Dermatology
                calcium hydroxylapatite,dermal filler,body vectoring,thighs,brachial zone,abdomen
                Dermatology
                calcium hydroxylapatite, dermal filler, body vectoring, thighs, brachial zone, abdomen

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