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      GlnR-mediated regulation of nitrogen metabolism in Lactococcus lactis.

      Journal of Bacteriology
      Bacterial Proteins, genetics, Base Sequence, Gene Expression Regulation, Bacterial, Glutamine, Lactococcus lactis, growth & development, metabolism, Molecular Sequence Data, Nitrogen, Operon, Quaternary Ammonium Compounds, Trans-Activators

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          Abstract

          We show that the nitrogen regulatory protein GlnR of Lactococcus lactis represses transcription of the amtB-glnK, glnRA, and glnPQ operons. This likely occurs through a conserved DNA motif, 5'-TGTNA-7N-TNACAT-3', and takes place in response to extracellular glutamine and ammonium. GlnR-independent repression of amtB-glnK is mediated by the pleiotropic nitrogen regulator CodY.

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