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Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation
Xinlu Ding ,
Sanxiong Liu ,
Miaomiao Tian ,
Wenhao Zhang ,
Tao Zhu ,
Dongdong Li ,
Jiawei Wu ,
HaiTeng Deng ,
Yichang Jia ,
Wei Xie ,
Hong Xie ,
Ji-Song Guan
March 27 2017
March 27 2017
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Relatively little is known about the mechanisms that preserve memories during long-term storage. The authors found that neural activation during learning triggers long-lasting transcription of a specific neurexin-1 splice isoform, enabling retention of hippocampus-dependent memory. This process was mediated by signaling through the AMPK pathway leading to histone modifications.