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      Periprosthetic joint infections after total hip replacement: an algorithmic approach

      review-article
      1 , * , 2
      SICOT-J
      EDP Sciences
      Periprosthetic, Joint, Infection, Hip replacement, Arthroplasty

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          Abstract

          An algorithm for managing periprosthetic joint infections (PJIs) after total hip replacement (THR) surgery using a multidisciplinary approach and a clearly defined protocol may improve infection eradication rates. In this article, we present an algorithm for the management of different types of PJIs including the acutely infected cemented and cementless THRs where the components are well-fixed postoperatively and when the infection is secondary to haematogenous spread in previously well-functioning and well-fixed implants. For chronic PJIs where the components are often loose, the standard treatment includes a two-stage revision procedure. However, in a highly selected subset of patients, a single-stage approach has been utilised with high rates of eradicating infections.

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          Most cited references58

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          Definition of periprosthetic joint infection.

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            Radiological Demarcation of Cemented Sockets in Total Hip Replacement

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              Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group.

              A prospective study was performed to establish criteria for the microbiological diagnosis of prosthetic joint infection at elective revision arthroplasty. Patients were treated in a multidisciplinary unit dedicated to the management and study of musculoskeletal infection. Standard multiple samples of periprosthetic tissue were obtained at surgery, Gram stained, and cultured by direct and enrichment methods. With reference to histology as the criterion standard, sensitivities, specificities, and likelihood ratios (LRs) were calculated by using different cutoffs for the diagnosis of infection. We performed revisions on 334 patients over a 17-month period, of whom 297 were evaluable. The remaining 37 were excluded because histology results were unavailable or could not be interpreted due to underlying inflammatory joint disease. There were 41 infections, with only 65% of all samples sent from infected patients being culture positive, suggesting low numbers of bacteria in the samples taken. The isolation of an indistinguishable microorganism from three or more independent specimens was highly predictive of infection (sensitivity, 65%; specificity, 99.6%; LR, 168.6), while Gram staining was less useful (sensitivity, 12%; specificity, 98%; LR, 10). A simple mathematical model was developed to predict the performance of the diagnostic test. We recommend that five or six specimens be sent, that the cutoff for a definite diagnosis of infection be three or more operative specimens that yield an indistinguishable organism, and that because of its low level of sensitivity, Gram staining should be abandoned as a diagnostic tool at elective revision arthroplasty.
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                Author and article information

                Journal
                SICOT J
                SICOT J
                sicotj
                SICOT-J
                EDP Sciences
                2426-8887
                2019
                28 February 2019
                : 5
                : ( publisher-idID: sicotj/2019/01 )
                : 5
                Affiliations
                [1 ] Foothills Medical Centre 1403 29 St NW Calgary AB T2N 2T9 Canada
                [2 ] University College London Hospital 235 Euston Road London NW1 2BU UK
                Author notes
                [* ]Corresponding author: msukeik@ 123456hotmail.com
                Article
                sicotj180064 10.1051/sicotj/2019004
                10.1051/sicotj/2019004
                6394232
                30816089
                9fe35085-8d5d-40a3-97fe-3655b7f8d56a
                © The Authors, published by EDP Sciences, 2019

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 05 June 2018
                : 28 January 2019
                Page count
                Figures: 0, Tables: 1, Equations: 0, References: 60, Pages: 6
                Categories
                Hip
                Review Article

                periprosthetic,joint,infection,hip replacement,arthroplasty
                periprosthetic, joint, infection, hip replacement, arthroplasty

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