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      Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database.

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          Abstract

          The hepatotoxic potential of the analgesic flupirtine has attracted increased attention over the past years. Recently, risk minimisation measures such as maximum treatment duration of 2 weeks have been requested by the European Medicines Agency (EMA). This study was conducted to further elucidate the clinical pattern of flupirtine-induced liver injury (FILI).

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          Author and article information

          Journal
          Eur. J. Clin. Pharmacol.
          European journal of clinical pharmacology
          Springer Nature
          1432-1041
          0031-6970
          Apr 2014
          : 70
          : 4
          Affiliations
          [1 ] Department of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
          Article
          10.1007/s00228-013-1631-4
          24366502
          9ffa3843-b073-4284-bc4b-ee3acfb06fa3
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