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      Synthesis, characterization and biological screening of sulfonamides derived form 2-phenylethylamine.

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          Abstract

          In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). These derivatives were characterized by IR, (1)H-NMR and EI-MS and then screened against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase enzyme (LOX) and were found to be potent inhibitors of butyryl cholinesterase only.

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          Author and article information

          Journal
          Pak J Pharm Sci
          Pakistan journal of pharmaceutical sciences
          1011-601X
          1011-601X
          Oct 2012
          : 25
          : 4
          Affiliations
          [1 ] Department of Chemistry, Government College University, Lahore, Pakistan. azizryk@yahoo.com
          Article
          23009998
          a00a45f6-0162-4503-9a5c-2628557cc980
          History

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