Elevated Flt3L Predicts Long-Term Survival in Patients with High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms.

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Abstract

The clinical management of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) is challenging due to disease heterogeneity, illustrating the need for reliable biomarkers facilitating patient stratification and guiding treatment decisions. FMS-like tyrosine kinase 3 ligand (Flt3L) is emerging as a prognostic or predictive surrogate marker of host tumoral immune response and might enable the stratification of patients with otherwise comparable tumor features.

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Journal

Journal ID (iso-abbrev): Cancers (Basel)

Title: Cancers

Publisher: MDPI AG

ISSN: 2072-6694

ISSN (Print): 2072-6694

Publication date (Electronic): Sep 04 2021

Volume: 13

Issue: 17

Affiliations

[1 ] Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.

[2 ] Knowledge Management in Bioinformatics, Institute for Computer Science, Humboldt-Universität zu Berlin, 12489 Berlin, Germany.

[3 ] Institute of Pathology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

[4 ] German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

[5 ] Department of Surgery, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.

[6 ] Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine, University Düsseldorf, 40225 Düsseldorf, Germany.

[7 ] Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology (BIMSB), 10115 Berlin, Germany.

Article

Publisher Item ID: cancers13174463

DOI: 10.3390/cancers13174463

PMC ID: 8430927

PubMed ID: 34503273

SO-VID: a021aace-7f1a-4712-9855-24ff518ae879

History

Keywords: neuroendocrine neoplasm,cytokine,circulating biomarker,Flt3L,immuno-oncology,tumor microenvironment

Data availability:

Keywords: neuroendocrine neoplasm, cytokine, circulating biomarker, Flt3L, immuno-oncology, tumor microenvironment

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