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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
March 31 1995
March 31 1995
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Abstract
<p class="first" id="d9152426e89">The interleukin-1 beta (IL-1 beta) converting enzyme
(ICE) processes the inactive
IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice
harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1
alpha (IL-1 alpha) after stimulation with lipopolysaccharide. Export of tumor necrosis
factor-alpha and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes
from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing
radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect
in apoptosis, ICE-/- mice proceed normally through development.
</p>