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      Neuronal Control of Brown Fat Activity.

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          Abstract

          Brown adipose tissue (BAT) activation reduces body fat and metabolic disorders by the enhanced combustion of lipids and glucose into heat. The thermogenic activity of brown adipocytes is primarily driven by the sympathetic nervous system (SNS) and controlled by the brain. In this review, we present recent advances in understanding how cues, such as temperature, light, and proteins, modulate the activity of brown fat by acting on the various hypothalamic nuclei. Given that activated BAT has a high capacity to take up and burn fatty acids (FAs) and glucose, pharmacological stimulation of brown fat in humans by either targeting the hypothalamus or mimicking outflow of the sympathetic nervous system might help improve glucose metabolism and insulin sensitivity, and also lower body fat.

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          Author and article information

          Journal
          Trends Endocrinol. Metab.
          Trends in endocrinology and metabolism: TEM
          1879-3061
          1043-2760
          Nov 2015
          : 26
          : 11
          Affiliations
          [1 ] Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.
          [2 ] Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address: P.C.N.Rensen@lumc.nl.
          Article
          S1043-2760(15)00185-X
          10.1016/j.tem.2015.09.008
          26482876
          a0416472-28f2-4ff1-b3c5-d04b2510a157
          Copyright © 2015 Elsevier Ltd. All rights reserved.
          History

          Brown adipose tissue,hypothalamus,sympathetic nervous system,thermogenesis,uncoupling protein 1

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